سهراب حاجی زاده
[ 1 ] - بررسی میزان بیان HIF1α در پدیده تحمل به ایسکمی القاء شده به واسطه هیپراکسی نورموباریک متناوب در مدل سکته مغزی موش صحرایی
زمینه و هدف: اخیراً نشان داده شده هیپراکسی نورموباریک اثر درمانی قابل ملاحظه‌ای در درمان ایسکمی حاد دارد که اصطلاحاً پیش شرطی‌سازی نامیده می‌شود. به هر حال به خوبی مشخص نیست این پیش‌شرطی در محیط زنده چگونه عمل می‌کند. در مطالعه حاضر اثر هیپراکسی نورموباریک متناوب بر بیان HIF1α در مدل سکته مغزی مورد مطالعه قرار گرفت. مواد و روش‌ها: مطالعه از نوع تجربی بوده و حیوانات شامل4 گروه، هر گروه شامل 6 موش...
[ 2 ] - بررسی اثر ورزش و تجویز مزمن ناندرولون دکانوئیت بر میزان بیان کانال های پتاسیمی حساس به ATP سارکولم در قلب موش صحرایی
سابقه و هدف: استروئید های آندروژنیک آنابولیک با تحریک سنتز پروتئین سبب افزایش اندازه و عملکرد عضله می شوند. میوسیت های قلبی دارای دو نوع کانال پتاسیمی حساس به ATP در سارکولم (sarcKATP) و میتوکندری (mitoKATP) می باشند. این کانال ها با باز شدن خود به عنوان یک مکانیسم محافظت کننده قلبی در برابر آسیب های ایسکمی خون رسانی مجدد عمل می نمایند. هدف از این مطالعه بررسی تأثیر استفاده از ناندرولون بر بیان...
[ 3 ] - CEREBRAL BLOOD FLOW REGULATION IN ANESTHETIZED MORPHINE DEPENDENT RATS: THE ROLE OF THE ADENOSINE SYSTEM
Adenosine has many of the characteristics of a regulator of cerebral blood flow and adenosine receptors change in morphine dependency. In this study the changes in adenosine receptors' responsiveness of pial vessels in the hind limb area of the sensory cortex were evaluated in morphine dependent rats (MDR) using the laser Doppler flowmetry technique. Adult male Sprague Dawley rats (250-350 ...
[ 4 ] - Effects of preconditioning with intermittent normobaric hyperoxia on TNFR1 and TNFR2 expression in the rat brain
Introduction: Recent studies have shown that intermittent normobaric hyperoxia (HO) protects the rat brain from ischemia reperfusion injury. However, the exact mechanism of this kind of protection in vivo is not known. In this study, the effect of HO on expression of TNFR1 and TNFR2 in a stroke model was investigated. Methods: In this experimental study, rats were divided into 4 groups: no...
[ 5 ] - A novel isolated dual perfusion/superfusion heart model for physiological and pharmacological evaluation of mammalian heart preparations
Abstract Introduction: Isolated perfused heart models such as perfusion and superfusion are commonly used for mammalian heart research. However, there are several fundamental limitations in the current techniques. In perfusion model, a suitable cannula is connected to the aorta and the perfusion is retrogradely performed. But, electrode displacement is a potential unwanted event resulted fr...
[ 6 ] - Evaluation of UCP2 expression in the phenomenon of ischemic resistance induced by alternating normobaric hyperoxia in a rat model of stroke
Introduction: ischemic preconditioning is one of the most important mechanisms, responsible for the increased brain resistance after stroke. One of the most important candidates to ischemia preconditioning is intermittent normobaric hyperoxia. In this study, the effect of intermittent normobaric hyperoxia on the expression of UCP2 was investigated in a stroke model. Methods: Rats were divid...
[ 7 ] - Decreased Uncoupling Protein 2 and 3 (UCP2 and UCP3) mRNA expression by endurance exercise training with and without chronic administration of nandrolone in rat heart
Introduction: The effect of regular exercise in decreasing the incidence of heart diseases is well known. The abuse of anabolic androgenic steroids (AAS) has been associated with cardiovascular disorders. Uncoupling proteins (UCPs) transport protons across the inner mitochondrial membrane thereby proton gradient can be diminished by the action of UCPs. This process will result in the uncoupl...
[ 8 ] - Effects of pretreatment with non hypotensive dose of ramiprilat and losartan on myocardial ischemia-reperfusion induced arrhythmias and infarct size in rats
Introduction: Inhibition of renin angiotensin system represents an important approach in the management of cardiovascular diseases. The aim of this study was to explore the effects of pretreatment with non-hypotensive dose of angiotensin converting enzyme (ACE) inhibitor, ramiprilat and angiotensin type 1 (AT1) receptor blocker, losartan on myocardial infarct size and arrhythmias in a rat mo...
[ 9 ] - Postnatal developmental alterations in the locus coeruleus neuronal fast excitatory postsynaptic currents mediated by ionotropic glutamate receptors of rat
Introduction: In the present work, spontaneous postsynaptic currents were assessed to investigate the postnatal development of excitatory postsynaptic currents in locus coeruleus neurons. Methods: In this study, AMPA and NMDA receptor-mediated spontaneous synaptic currents in the neurons of locus coeruleus were assessed using whole cell voltage-clamp recording during the first three weeks. ...
[ 10 ] - The Role of NO and cGMP in vasodilatory effect of β2-adrenoceptors in rat skin
Introduction: In recent study both endothelium-dependent and endothelium-independent mechanisms have been reported for the action of β-adrenoceptor. The aim of this study was to investigate on the role of nitric oxide (NO) and cyclic guanosin monophosphate (cGMP) in vasodilation mechanisms of β2-adrenoceptors (β2-AR) in rat skin vessels. Methods: All drugs were injected subcutaneous into p...
[ 11 ] - Decrease of the responsiveness of beta-2 adrenoceptors of diabetic rat knee joint blood vessels in acute inflammation
Beta-2 adrenoceptors in blood vessels are one of the active factors that play a role in regulation of tissue blood flow. in diabetic angiopathy, responsiveness of these receptors is decreased, while that is increased in inflammation. According to these opposite effects, the aim of this study was to investigate the vasodilatory response of knee joint blood vessels to salbutamol (Beta-2 adreno...
[ 12 ] - Effects of normobaric hyperoxia pretreatment on ischemia-reperfusion injury in regional ischemia model of isolated rat heart
Abstract Introduction: Resent studies have been shown beneficial effects of hyperoxia pretreatment against ischemia-reperfusion injury in different organs. The aim of the present study was to investigate early and late effects of normobaric hyperoxia (≥95% O2) pretreatment on ischemia-reperfusion injuries in isolated rat hearts. Methods: Following 60 and 180 minutes of hyperoxia, rat hearts w...
[ 13 ] - The role of adenosine A2 receptors in regulation of pial vessels blood flow in anesthetized morphine dependent rats.
Introduction:Adenosine as a potent vasodilator has physiological role in regulation of regional cerebral blood flow (rCBF). Metod: Laser-Dِoppler flowmetry technique was used to study pial vessels blood flow responses to adenosine receptors agonists and antagonist. Male Sprague Dawley rats (250-350g) that were housed in standard conditions, were anesthetized with Urethane (1.5g/kg). Adenosine ...
[ 14 ] - Investigation on the vasodilatory effect of insulin through KATP channels and NO pathway in the skin vessels of native and diabetic rats
Introduction: Endothelium and smooth muscle dysfunction are the most important complications of diabetes. In type 1 diabetic patients, absence of insulin leads to vasoconstriction and lower skin blood perfusion. Release of some mediators by endothelium which is induced by insulin causes vasodilation, but the exact mechanism of insulin vasodilatory effect is not detected properly. At present st...
[ 15 ] - Study on the effect of neuroprotective prolonged and intermittent normobaric hyperoxia on serum level of TNF-α and glutamate transporters expression in rat brain
Introduction: Prolonged and intermittent oxygen pre-exposure is associated with protection against ischemic reperfusion (IR) injury. In the current study, attempts were made to investigate the relationship between exposure to prolonged and intermittent normobaric hyperoxia (NBHO) and expression of excitatory amino acids transporters (EAATs) and TNF-α level. Method: Rats were divided into fo...
[ 16 ] - اثر هیپراکسی نورموباریک متناوب و فعالیت پروتیئن کیناز C بر نفوذپذیری سد خونی – مغزی در رت
زمینه و هدف: اخیراً نشان داده شده هیپراکسی نورموباریک متناوب اثر درمانی قابل ملاحظه ای در درمان ایسکمی حاد دارد. در مطالعه حاضر اثر هیپراکسی نورموباریک متناوب و فعالیت پروتیئن کیناز C در نفوذپذیری سد خونی – مغزی، همچنین ارزیابی رفتاری در رت بررسی شده است. روش بررسی: در این مطالعه تجربی 36 رت نژاد ویستار به 6 گروه شش تایی شامل: نورموکسی (شم)، نورموکسی + Chelerythrin chloride ( CHEL )، نورموکس...
نویسندگان همکار