A simple, sensitive Spectrophotometric determination of monoamine oxidase activity from tissue homogenates is described. This method is based on the high extinction coefficient of 4-hydroxy-3-methoxy-benzaldehyde (vanillin) at 345 nm at pH ~ 11.7. Vanillin is formed by inonoamine oxidase when 4-hydroxy-3-methoxy-benzylamine is used as substrate. The primary oxidation product, 4-hydroxy-3-methox...

The methanolic extract of the aerial parts of Salvia leriaefolia (labiatae) afforded 5-hydroxy-4´, 6, 7-trimethoxy flavone (Salvigenin) and (5,4´-dihydroxy-7-methoxy flavone (Genkwanin). The structures of the isolated compounds were elucidated using 1 and 2 D-NMR, IR, UV and MS.

In this study, the adsorption of 4-hydroxy phenyl-azobenzene on the surface of (4, 0) zigzag open-end boron nitride nanotube (BNNT) has been investigated by quantum calculations. In order to find the preferred adsorption site, different positions and orientations were considered. The impacts of donor-acceptor electron delocalization on the structural and electronic properties and reactivity of ...

In this study, the adsorption of 4-hydroxy phenyl-azobenzene on the surface of (4, 0) zigzag open-end boron nitride nanotube (BNNT) has been investigated by quantum calculations. In order to find the preferred adsorption site, different positions and orientations were considered. The impacts of donor-acceptor electron delocalization on the structural and electronic properties and reactivity of ...

this study describes the organic synthesis of 5-(2-amimo-4-styryl pyrimidine-4-yl)-4-methoxy benzofuran-6-ol (spbf) as an example of a benzofuran derivative used as a new series of amyloid imaging agents. these benzofuran derivatives may be useful amyloid imaging agents for detecting b-amyloid plagues in the brain of alzheimer’s disease. the precursor is 1-[6-hydroxy-4-methoxybenzofuran-5-yl]-p...

Ethoxy-, methoxy- and hydroxy-terminated polydimethylsiloxanes (PDMS) are formed as the result of the methanolysis of diethoxy-ended PDMS during its infusion in electrospray ionization. The negative ion mode permits only hydroxy-ended products to be detected, and isomeric interference is avoided in single stage and tandem mass spectrometry. The routes for the fragmentation of (ethyl, hydroxy)-,...

Interest in central neurokinin (NK) 1 receptors has increased based on reports of the therapeutic potential for NK1 antagonists in anxiety and depression. In these studies, an ex vivo binding procedure was used to correlate NK1 receptor occupancy in striatum by NK1 antagonists with their potency to inhibit NK1 agonist-induced foot tapping in gerbils (GFT). The following compounds were administe...

Abstract: We designed three unsymmetrical meso-tetrasubstituted phenyl porphyrins for further development as theranostic agents for cancer photodynamic therapy (PDT): 5-(4-hydroxy-3-methoxyphenyl)-10,15,20-tris-(4-acetoxy-3-methoxyphenyl)porphyrin (P2.2), Zn(II)-5-(4-hydroxy-3-methoxyphenyl)-10,15,20-tris-(4-acetoxy-3-methoxyphenyl)porphyrin (Zn(II)2.2) and Cu(II)-5-(4-hydroxy-3-methoxyphenyl)-...

Continuing our antecedent work against COVID-19, a set of 5956 compounds traditional Chinese medicine have been virtually screened for their potential SARS-CoV-2 helicase (PDB ID: 5RMM). Initially, fingerprint study with VXG, the ligand target enzyme, disclosed similarity 187 compounds. Then, molecular declared most similar 40 Subsequently, docking studies were carried out to examine binding mo...

A biocatalytic transformation has the potential to perform organic reactions that are quite challenging achieve with synthetic chemistry. They also catalyze these a chemo and enantio selective manner. The discovery development of new chemoenzymatic methods for synthesis chiral structures is essential production wide range bioactive compounds. In this study, two important pharmaceutical precurso...