We examine whether Phellodendron amurense (PA) and its major alkaloid compound, berberine (BER), improved memory defects caused by administering scopolamine in rats. Effects of PA and BER on the acetylcholinergic system and pro-inflammatory cytokines in the hippocampus were also investigated. Male rats were administered daily doses for 14 days of PA (100 and 200 mg/kg, i.p.) and BER (20 mg/kg, ...

Oxidative stress is thought to play a role in the pathogenesis of Alzheimer's disease (AD) and increased oxidative DNA damage has been observed in brain tissue from AD patients. Base excision repair (BER) is the primary DNA repair pathway for small base modifications such as alkylation, deamination and oxidation. In this study, we have investigated alterations in the BER capacity in brains of A...

The production and characterization of a monoclonal antibody (MoAb) designated Ber-H2, directed against a new epitope of the Ki-1 (CD30) antigen, are described. In comparison with the formerly reported Ki-1 MoAb whose reactivity with Hodgkin and Reed-Sternberg (H-RS) cells in frozen tissue sections is well-documented, the Ber-H2 MoAb showed new, important features: the labeling intensity of the...

The bit error rate of data signal (data BER) a key-based physical layer authentication (PLA) scheme suffers from non-negligible performance loss, mainly caused by the tags taking power symbols and interfering with demodulation. Considering orthogonality among different orbital angular momentum (OAM) modes, in this paper, an OAM-assisted PLA (OAM-PLA) is proposed to improve BER. BER OAM-PLA over...

Base excision repair (BER) pathway is one of the repair systems that have an impact on the radiotherapy and chemotherapy for the cancer patients. The molecular pathogenesis of gallbladder cancer is not known extensively. In the present study we investigated whether the expression of AP endonuclease 1 (APE1) and DNA polymerase β (DNA pol β), key enzymes of BER pathway has any clinical ...

In this paper, a decode-and-forward cooperative communication system using hierarchical modulation (HM) to improve bit error probability (BER) performance is proposed. A HM symbol has high priority (HP) and low priority (LP) data streams that have different levels of BER. In the proposed scheme, all decoded symbols are treated as HP symbol by suitable design for cooperative communication. Conse...

In this letter a recursive and computationally efficient new formula for bit error rate (BER) in multipath channels with several specular components is derived. Using Jensen’s inequality it is shown that one specular component, Rice fading, provides the lowest possible BER. Using Lagrange multipliers to solve a constrained optimization problem, it is further shown that for two specular componen...

Base excision repair (BER) protects cells from nucleobase DNA damage. In eukaryotic BER, DNA glycosylases generate abasic sites, which are then converted to deoxyribo-5'-phosphate (dRP) and excised by a dRP lyase (dRPase) activity of DNA polymerase beta (Polbeta). Here, we demonstrate that NEIL1 and NEIL2, mammalian homologs of bacterial endonuclease VIII, excise dRP by beta-elimination with th...