herbal medicines have been used for centuries to treat different illnesses. among more than 20,000 herbal medicines available for humans, a limited number have sufficiently been studied and numerous remained to be investigated for their efficacy in treating human diseases. a number of herbal products are in use for their immunosuppressive effects. this capacity of herbs may have useful applicat...

aloe littoralis baker (asphodelaceae family) is a well known plant in southern parts of iran. because of its use in iranian traditional medicine as a wound-healing agent, the present study was carried out to investigate anti-inflammatory and wound healing activities of this plant in wistar rats. a. littoralis raw mucilaginous gel (alrmg) and also two gel formulations prepared from the raw mucil...

Anti-inflammatory effects of acetonic and methanolic extracts of aerial parts of Stachys byzanthina were investigated in this study. For assessment of anti-inflammatory properties, two well-characterized inflammatory models, formalin test and carrageenan-induced paw edema were used. In the former, the recording of the early phase started immediately after formalin injection and lasted for 10 mi...

cognitive impairments describe a state of diminished or impaired mental and/or intellectual function such as alzheimer's disease, huntington's disease and parkinson's disease. as these disorders are more frequent in the elderly and due to the ageing of population, serious attention must be paid to these diseases. exercise has shown to have preventive and therapeutic effects on co...

Inflammatory processes have been shown to be involved in development and progression of neurodegenerative diseases. Mammalian target of rapamycin (mTOR) involves in various cellular processes including autophagy, apoptosis and energy metabolism. Recently, studies have been shown an association between mTOR pathway and inflammation, supporting the role of the pathway in the pathogenesis of infla...

Objective(s): In the present study, we investigated the potential anti-nociceptive activity and acute anti-inflammatory effect of a synthetic quinoline compound (2-(4-Methoxyphenyl)benzo[h]quinoline-4-carboxylic acid, QC), possessing structural elements of both naproxen and tomoxiprole drugs. Materials and Methods: The anti-nociceptive activity of QC was evaluated using chemical- and thermal-in...

rheumatoid arthritis (ra) is a chronic autoimmune disease, which can lead to joint destruction and disability. pannus formation due to chronic synovitis is the hallmark of ra. oxidative stress as a consequence of immune cell activation and disease-modifying anti-rheumatic drugs can prevent inflammation and tissue destruction. silymarin, an antioxidant extract from silybum marianum, has been tra...

Background: Ghrelin is a peptide with attenuating effect on inflammatory pain. Both anti- and pro-inflammatory mediators have a role in the nociception and development of pain and hyperalgesia. IL-10 and TGF-β are anti-inflammatory cytokines and inhibit the expression of pro-inflammatory cytokines related to peripheral and central inflammatory pain. In this study, the effects of i.p. injec...

objective: pharmacological effects of carvacrol such as its anti-inflammatory activities have been shows. in this study the effects of carvacrol on serum levels of total protein (tp), phospholipase a2 (pla2) and histamine in sensitized guinea pigs was evaluated. materials and methods: sensitized guinea pigs were given drinking water alone (group s), drinking water containing three concentration...