The relative effects of chronic pressure overload and chronic volume overload on left ventricular diastolic chamber stiffness were examined using a combined hemodynamic and ultrasonic technique in 27 patients. The slope of the left ventricular pressure-diameter relation in late diastole was measured and found to be steep in the groups with pressure or volume overload (9.0 ± 1.8 mm Hg/mm for pre...

Torsoni, Adriana S., Priscila M. Fonseca, Daniela P Crosara-Alberto, and Kleber G. Franchini. Early activation of p160ROCK by pressure overload in rat heart. Am J Physiol Cell Physiol 284: C1411–C1419, 2003. First published February 5, 2003; 10.1152/ajpcell.00098.2002.—We investigated the effects of acute pressure overload on activation of p160ROCK in rat myocardium. Constriction of transverse ...

Schwarzer M, Schrepper A, Amorim P, Osterholt M, Doenst T. Pressure overload differentially affects respiratory capacity in interfibrillar and subsarcolemmal mitochondria. Am J Physiol Heart Circ Physiol 304: H529 –H537, 2013. First published December 15, 2012; doi:10.1152/ajpheart.00699.2012.—Years ago a debate arose as to whether two functionally different mitochondrial subpopulations, subsar...

Although pressure overload induces cardiac hypertrophy and reexpression of contractile protein isogenes, the molecular mechanism of both is not well understood. We demonstrated the early change in the translational activity of specific cardiac messenger RNA by two-dimensional gel electrophoresis of in vitro translational products. A total of over 400 translational products were detected by fluo...

Study of left ventricular pressure-volume relations in man has been limited by technical problems associated with left ventricular angiography. A new approach to this problem using simultaneous recording of left ventricular pressure and left ventricular volume (determined by echocardiography) was applied in 21 patients. Pressure-volume plots, constructed from pressure and volume values sampled ...

RATIONALE Pressure overload induces adaptive remodeling processes in the heart. However, when pressure overload persists, adaptive changes turn into maladaptive alterations leading to cardiac hypertrophy and heart failure. ATF3 is a stress inducible transcription factor that is transiently expressed following neuroendocrine stimulation. However, its role in chronic pressure overload dependent c...