Radiation-induced lung injury is one of the most prominent factors that interfere with chest cancer radiotherapy, and poses a great threat to patients exposed to total body irradiation. Upregulation of pro-oxidant enzymes is one of the main mechanisms through which the late effects of ionizing radiation on lung injury can be exerted. Interleukin (IL)-4 and IL-13 are two important cytokines that...

Asthma is currently defined as a chronic inflammatory disorder of the airways. The central role of allergen-specific Th2 cells in the regulation of this mucosal airway inflammation has been highlighted. Hence, there is large interest in the therapeutic potential of an anti-Th2 cell approach. One of the strategies which has been developed, is to inhibit the effect of interleukin (IL)-4 or IL-5, ...

Objective: To observe the efficacy of Montelukast combined with sublingual immunotherapy (SLIT) in treatment children obstructive sleep apnea hypopnea syndrome (OSAHS) complicated allergic rhinitis (AR).
 Methods: This is a prospective study. A total 102 OSAHS admitted to Hunan Children’s Hospital from April 2020 2021 were selected and randomly divided into two groups: group two-drug combi...

results mean urinary il-1α, il-4, il-6, and il-8 concentrations significantly increased in the acute phase of apn compared to the control group, and decreased following antibiotic treatment. conclusions we recommend routine urinalysis and urine culture for the diagnosis of children with apn. urinary il-4 was a relatively good cytokine for the prediction and treatment-monitoring of children with...

The exacerbation of asthma during viral infections is mainly explained by neutrophils infiltrating into the airways. However, enhanced functions of eosinophils are also observed. The aim of this study was to reveal the mechanism of how eosinophils are activated during and after viral infection of the airways, using a model of viral infection. A synthetic double-stranded RNA, poly inosinic-cytid...

N-Acetyl-L-cysteine (NAC) is an antioxidant precursor of intracellular glutathione (GSH), usually given in human as a mucolytic agent. In vitro, NAC and GSH have been shown to act on T cells by increasing interleukin (IL) 2 production, synthesis and turnover of IL-2 receptors, proliferation, cytotoxic properties, and resistance to apoptosis. We report here that NAC and GSH decrease in a dose-de...

Group 2 innate lymphoid cells (ILC2s), characterized by secretion of type cytokines, regulate multiple immune responses. ILC2s are found in different tumor tissues, and ILC2-derived interleukin (IL)-4, IL-5, IL-13 act on the microenvironment to participate progression. abundant colorectal cancer (CRC) tissue, but role CRC remains unclear. In this study, we that percentage was higher tissue than...

Pemphigus vulgaris (PV) is a chronic autoimmune blistering disease of the skin, in whichloss of adhesion between keratinocytes is caused by autoantibodies. It has been hypothesizedthat cytokines play an essential role in the pathogenesis of PV. This study aimed to investigatethe other immunopathological aspects of PV by determining the serum levels of cytokines inPV patients to find another tre...

Abstract Canine atopic dermatitis (CAD) is a prevalent genetically susceptible inflammatory and pruritic allergic skin condition affecting not only the health of dogs but also quality life their owners. Interleukin-31 (IL-31) interleukin-31 receptor alpha (IL-31RA) are essential for development pruritus in primates mice. Hence, it expected that inhibiting IL-31RA will be an effective approach t...