Electrostatic interactions are of vital importance in diverse aspects of protein structure and function [1-5], including the catalytic activity [6,7], ligand binding [8], complex formation [9], proton transport [10,11], as well as their stability of folded proteins [12,13]. These interactions involve full charges on the side chains of ionizable amino acids that arise from the association and di...

This paper describes the wetting by water of monolayer fibns formed bythe spontaneous assemblyof fong-cfifr;1*anethioG, HS(CH;rJX, onto gold surfaces, w\e1e X = carboxylgJ,.e.$-o-sph93ate' 5-tetra?olo, f -iiiarroto, or 2-imidrioto. 'Mon6iayers weie also generated from mixtures of HS(CHdtd ald HS(CHs)ra CH" ffe wetting by water of the single-component and the mixed surfaces was examined as a fun...

Nanoscale analysis may be used to design new types of mucoadhesive polymers. Understanding of the surface interactions between hydrophilic polymer surfaces and mucins can lead to improved adhesive bonding by hydrogen bonding. Alternatively, decoration of a mucoadhesive polymer surface with tethers of linear and block copolymers containing neutral or ionizable structures provides increased inter...