Abstract The aim of the research was to evaluate response three tropical species (Heliconia psittacorum, Ciperus haspan, Hedychium coronarium), respect their tolerance and removal capacity pharmaceutical personal care products (PPCPs), namely acetylsalicylic acid, ibuprofen, methyl hydrojasmonate (cis – MDJM), galaxolide, tonalide, caffeine, naproxen, ketoprofen, diclofenac. study undertaken in...

Objectives: The treatment of pain after surgery is central to the care of postoperative patients. Non-steroidal anti-inflammatory drugs are devoid of side effects of opioids like respiratory depression, vomiting, cardiac depression etc. Ketoprofen, a nonsteroidal anti-inflammatory drug, being in use since 1974, is not a much-studied drug. We decided to compare Ketoprofen and Diclofenac sodium f...

BACKGROUND Non-steroidal anti-inflammatory drugs (NSAIDs) can reduce postoperative pain, in both static (i.e., at rest) and dynamic contexts (e.g., during coughing or mobilization), and reduced doses could improve their efficacy/tolerance balance. OBJECTIVES To test this hypothesis of efficacy after open heart surgery, in which NSAIDs are poorly used, particularly for safety concerns. STUDY...

BACKGROUND Multimodal analgesia combining several non-opioid analgesics is recommended for pain control after surgery. In one study of total hip arthroplasty (THA), pain relief achieved by adding ketamine to the paracetamol-ketoprofen combination was statistically significant but remained inadequate in most patients. In two other studies, the analgesic effect of nefopam was synergistic with tha...

BACKGROUND To evaluate the analgesic effect and tolerability of paracetamol syrup compared to placebo and ketoprofen lysine salt in children with pharyngotonsillitis cared by family pediatricians. METHODS A double-blind, randomized, placebo-controlled trial of a 12 mg/kg single dose of paracetamol paralleled by open-label ketoprofren lysine salt sachet 40 mg. Six to 12 years old children with...

The purpose of this study was to evaluate the efficacy of an oral solution of ketoprofen administered in drinking water at a lower dose as a complement to antimicrobial therapy in a mild outbreak of porcine respiratory disease complex. The study was performed with 120 pigs with rectal temperature between 39.9 and 41°C and at least 1 sign indicating porcine respiratory disease complex (dyspnea, ...

This study aimed to qualify photosafety screening on the basis of photochemical and pharmacokinetic (PK) data on dermally applied chemicals. Six benzophenone derivatives (BZPs) were selected as model compounds, and in vitro photochemical/phototoxic characterization and dermal cassette-dosing PK study were carried out. For comparison, an in vivo phototoxicity test was also conducted. All of the ...

Photodeprotection is an important reaction that has been attracting broad interest for use in a variety of applications. Recent advances in ultrafast and vibrational time-resolved spectroscopies can facilitate obtaining data to help unravel the reaction mechanisms involving in the photochemical reactions of interest. The kinetics and reaction mechanisms for the photodeprotection reactions of ke...

BACKGROUND Postoperative abdominal and shoulder pain are the most common complaints after elective laparoscopic cholecystectomy. Postoperative pain is multifactorial in origin, and therefore multimodal therapy may be needed to optimize pain relief. METHODS We conducted a double-blind study where patients were randomly allocated to 1 of 5 groups of 20 patients each. Statistical significance wa...