Background: Dendritic cells (DC) are a key regulator of the immune response, and interferon- beta (IFN-β) is considered an immunomodulatory molecule for DC. Objective: The purpose of this study was to evaluate the ability of IFN-β treated DC to induce cytokine secretion by CD4+ T cells. Methods: Dendritic cells were generated from blood monocytes with granulocyte-monocyte colony-stimulating fac...

background: because of high morbidity of the brucellosis in humans and the potential use of the microorganism as an agent of biologic warfare, protection of effective vaccines and specific diagnostic reagents become necessary to eradicate brucellosis. objective: in this study we aimed to investigate the cytokine responses and changes in peripheral blood lymphocyte subgroups of acute brucellosis...

PURPOSE The purpose of this study was to evaluate Interferon (IFN)-γ and Interleukin(IL)-17 profiles in patients with different clinical presentations of pulmonary tuberculosis (TB) and to compare them with those of tuberculin-negative and tuberculin-reactive healthy controls METHODS Peripheral blood mononuclear cells (PBMCss), isolated from patients (n=52) and controls (n=30), were stimulate...

background: the relationship of inflammatory cytokines with anxiety and depression has been reported, but their role in diabetic patients has not been fully elucidated. objective: we examined whether an association between prevalence of anxiety and depression in omani type-2 diabetic patients (n=30) and the levels of inflammatory markers such as il-1β, tnf-α, ifn-γ and c-reactive protein (crp) ...

Chronic granulomatous disease (CGD) is a rare immunodeficiency disorder in which phagocytic leukocytes fail to generate superoxide (O(2)(-)) and antimicrobial oxidants. The therapeutic validity of interferon-gamma (IFN-γ) has been well established in CGD patients but its underlying mechanisms remain poorly understood. One probable mechanism has been suggested to be modulation of nitric oxide (N...

Background: The relationship of inflammatory cytokines with anxiety and depression has been reported, but their role in diabetic patients has not been fully elucidated. Objective: We examined whether an association between prevalence of anxiety and depression in Omani type-2 diabetic patients (n=30) and the levels of inflammatory markers such as IL-1β, TNF-α, IFN-γ and C-reactive protein (CRP) ...

BACKGROUND Surfactant proteins are produced predominantly by alveolar type II (ATII) cells, and the expression of these proteins can be altered by cytokines and growth factors. Th1/Th2 cytokine imbalance is suggested to be important in the pathogenesis of several adult lung diseases. Recently, we developed a culture system for maintaining differentiated adult human ATII cells. Therefore, we sou...

Abstract The rabbit VX2 bone tumor model is an ideal animal for studying malignant tumors. Cytokines have been reported to play a role in initiation and promotion, angiogenesis, metastasis. However, few studies investigated the relationship between cytokines development. This study effect of interferon-γ (IFN-γ) interleukin-4 (IL-4) on proliferating cell nuclear antigen (PCNA) expression tissue...

about 25-50% of graves' disease (gd) patients develop thyroid eye diseases, which is associated with inflammatory process and abnormalities in the levels of several cytokines in orbital tissues in gd.  the aim of this study was to determine the th1 and th2 serum cytokines in patients with gd with or without ophthalmopathy. serum  levels of  cytokines  and  autoantibodies  including interferon-g...