This work deals with exploring some empirical scales of nucleophilicity. We have started evaluating the experimental indices of nucleophilicity proposed by Legon and Millen on the basis of the measure of the force constants derived from vibrational frequencies using a probe dipole H-X (X = F,CN). The correlation among some theoretical parameters with this experimental scale has been evaluated. ...

One hundred and five cases of various human lung neoplasms were studied immunohistochemically using monoclonal antibodies recognizing the antigens, Le(x), sialylated Le(x) (SLEX), Le(a), and sialylated Le(a) (SLEA). Of the 92 lung cancers examined for antigen expression SLEX was detected in 57% (52 cases), Le(x) in 42% (39), SLEA in 36% (33), and Le(a) in 23% (21). None of these antigens were e...

BACKGROUND Lewis y antigen is difucosylated oligosaccharide and is carried by glycoconjugates at cell surface. Elevated expression of Lewis y has been found in 75% of ovarian tumor, and the high expression level is correlated to the tumor's pathological staging and prognosis. This study was to investigate the effect and the possible mechanism of Lewis y on the proliferation of human ovarian can...

By employing a chiral Lewis base as the catalyst, enantioselective hydrosilylation of N-(1,2-diarylethylidene)arylamines was realized. The reactions proceeded smoothly to afford various chiral 1,2-diarylethanamines with good yields (up to 99%) in good enantioselectivities (up to 98%). Furthermore, one of the products was employed in the synthesis of a pharmaceutical substance.

We established a new congenic model of hypertension, the mRen(2). Lewis rat and assessed the intracellular expression of angiotensin peptides and receptors in the kidney. The congenic strain was established from the backcross of the (mRen2)27 transgenic rat that expresses the mouse renin 2 gene onto the Lewis strain. The 20-wk-old male congenic rats were markedly hypertensive compared with the ...

Bei Betrachtung der geometrischen und elektronischen Struktur des Tris(pentafluorethyl)silanids erscheint das Anion auf den ersten Blick als Lewis-Base. Quantenmechanischen Rechnungen zufolge liegen die HOMO- LUMO-Energien von Perfluoralkylsilaniden deutlich niedriger nicht fluorierter Derivate. Dies hat eine geringere Lewis-Basizität zugleich erhöhte Lewis-Acidität [Si(C2F5)3]−-Ions zur Folge....

asthma and chronic obstructive pulmonary disease (copd) are highly prevalent chronic diseases in the general population. both are characterized by similar mechanisms: airway inflammation, airway obstruction, and airway hyperresponsiveness. however, the distinction between the two obstructive diseases is not always clear. multiple epidemiological studies demonstrate that in elderly people with o...

Sialyl 6-sulfo Lewis X determinant has been described recently as a major ligand for L-selectin on high endothelial venules of human peripheral lymph nodes. From our investigation of its distribution in human colorectal cancer tissues and cultured colon cancer cells, the sialyl 6-sulfo Lewis X determinant was preferentially expressed in the nonmalignant colonic epithelia rather than cancer cell...

What sorts of properties should we use in building our conception of the way the world is? David Lewis offers one answer to this question; Robert Stalnaker offers another. Lewis suggests a reductionist picture, according to which we should strive to build our conception of the way the world is on the basis of fundamental (or ‘perfectly natural’) properties. Fundamental properties, according to ...