OBJECTIVE To investigate whether hyaluronidase (Hyalase) is a useful and justified addition to haematoma block for pain relief. METHODS The study was a randomised double blind trial of 33 consecutive patients attending the accident and emergency department for manipulation of distal radius fracture under haematoma block. Control patients received 1% lignocaine; the treatment group received 1%...

We have assessed the effects of intraplantar local anaesthetics (bupivacaine and lignocaine) on carrageenan-induced oedema, mechanical allodynia and spinal c-fos protein expression. Mechanical allodynia was evaluated using the vocalization threshold to paw pressure (VTPP) every 30 min until 60, 180 or 240 min after administration of carrageenan. Peripheral oedema, mechanical allodynia and spina...

The effects of regional intravenous analgesia in the upper limb were studied in eight subjects by means of clinical examination and serial nerve conduction techniques. The changes following 1 per cent lignocaine analgesia and ischaemia were compared with those following ischaemia alone; the latter produced analgesia and impairment of conduction at a considerably slower rate than it did when com...

We have studied in anaesthetized dogs the effects of alfentanil, fentanyl, pethidine and lignocaine administered intrathecally on nociceptive responses evoked by low and high frequency supramaximal electrical stimulation of the tibial and radial nerves. Doses were selected to abolish both A delta and C fibre somatosympathetic reflexes to single stimuli. Pethidine and lignocaine eliminated refle...

The addition of adrenaline 5 mug/ml, 1 : 200 000 to 1% etidocaine hydrochloride administered extradurally (L2-3) shortened significantly the onset time for sensory blockade, particularly with respect to the spread of the analgesia from the injection site, and shortened the already rapid onset of motor block. Etidocaine hydrochloride 1% plain caused a slower onset of block, laster longer and pro...

AIMS To test if the simple technique of warming lignocaine reduces the pain of injection during local anaesthetic cataract surgery. METHODS Sixty patients undergoing peribulbar local anaesthesia for cataract surgery were allocated randomly to receive either warm (37 degrees C) or cold (room temperature) plain 2% lignocaine for the injection. Pain was assessed subjectively by asking the patien...

Among the non-depolarizing neuromuscular blocking drugs, atracurium appears to be unique in its ability to produce cerebral stimulation in lightly anaesthetized animals. This effect is attributed to the atracurium metabolite, laudanosine. The following studies were performed to determine if pretreatments with the non-depolarizing neuromuscular blockers pancuronium, atracurium or vecuronium woul...

OBJECTIVE To assess the effect of a 40 mg methylprednisolone injection proximal to the carpal tunnel in patients with the carpal tunnel syndrome. DESIGN Randomised double blind placebo controlled trial. SETTING Outpatient neurology clinic in a district general hospital. PARTICIPANTS Patients with symptoms of the carpal tunnel syndrome for more than 3 months, confirmed by electrophysiologi...

Objective: To assess and compare the efficacy of lignocaine anesthesia of vocal cords by “spray as you go” through a bronchoscope with lignocaine injection through the cricothyroid membrane. Study Design: Quasi experimental study. Place and Duration of Study: This study was done in Combined Military Hospital Peshawar form May 2009 to June 2010. Material and Methods: Thirty patients in each grou...

BACKGROUND Pre-cancerous lesions of cervix (cervical intraepithelial neoplasia (CIN)) are usually treated with excisional or ablative procedures. In the UK, the National Health Service (NHS) cervical screening guidelines suggest that over 80% of treatments should be performed in an outpatient setting (colposcopy clinics). Furthermore, these guidelines suggest that analgesia should always be giv...