BACKGROUND/AIM A local nanotherapy (LNT) combining the therapeutic efficacy of trans-arterial embolization, nanoparticles, and p53 gene therapy has been previously presented. The study presented here aimed to further improve the incomplete tumor eradication and limited survival enhancement and to elucidate the molecular mechanism of the LNT. METHODS In a tumor-targeting manner, recombinant ex...

For the purpose of a global analysis of the effects of low radiation doses in mammals, the International Centre for Low Dose Radiation Research (ICLDRR) is collecting, in one database, all accessible information on cancer induction in animals following exposure to low doses and dose rates of ionizing radiation. A large number of these studies are identified and succinctly described in the Inter...

A novel and promising method to measure low levels of NOx utilizes the accumulating sensor principle. During an integration cycle, incoming NOx molecules are stored in a sensitive layer based on an automotive lean NOx trap (LNT) material that changes its electrical resistivity proportional to the amount of stored NOx, making the sensor suitable for long-term detection of low levels of NOx. In t...

in this research genetic and phenotypic parameters were estimated using linear and threshold models, for reproductive traits, data from 6 large industrial dairy herd of east azerbaijan province collected by agriculture jihad organization during 10 years (2001-2010). best linear unbiased predictions of traits breeding values were estimated using restricted maximum likelihood method by wombat sof...

The hormesis concept has broad implications for biology and the biomedical sciences. This perspective on hormesis concentrates on toxicology and toxicological risk assessment and secondarily explores observations from other fields. It considers the varied manifestations of hormesis in the context of a broad family of biological stress responses. Evidence for hormesis is reviewed, and the hormes...

This article suggests five classes of effort that scientists can undertake to destroy the linear no-threshold hypothesis as the basis of radiation regulation in the United States. These are (1) pressure on regulators such as the Nuclear Regulatory Commission, (2) presidential messages, (3) Congressional pressure, (4) educate physicians about low-dose radiation, and (5) work with journalists and...

A tightly reasoned justification is presented for the procedures used in our test of the linear-no threshold theory of radiation carcinogenesis by comparing lung cancer rates with average radon exposure in U.S. counties. A key point is its dependence on ecological variables rather than on characteristics of individuals and the principal problems involve treatment of potential confounding factor...

A H2O2-induced oxidative stress injury cell model was established to investigate the antioxidant effect of nano-selenium on mouse spermatocyte lines and regulation mechanism expression level activity selenium-containing enzymes induced by stress. safe effective nano-drug system functionalized nanoparticles (SeNPs) developed with lentinan (LNT) (SeNPs@LNT). Mice line GC2-spg cells were treated S...