BACKGROUND AND PURPOSE In the rat four-vessel occlusion model with 30 minutes of ischemia most agents have failed to be of benefit when given after ischemia. Because postischemia administration is more clinically relevant, we evaluated the antioxidant LY231617 (2,6-bis(1,1-dimethylethyl)-4-[[(1-ethyl)amino]methyl]phenol hydrochloride]) when administered after 30 minutes of four-vessel occlusion...

OBJECTIVES To investigate the combined effects of rosiglitazone and pravastatin on renal functions in early streptozotocin induced diabetic nephropathy (DN). METHODS This study was carried out at King Khalid University Hospital Animal House, Riyadh, Saudi Arabia from August 2013 to February 2014. Fifty male Wistar rats were assigned to normal control rats and diabetic rats that received salin...

With regard to the importance of antioxidants in foods, cosmetics and pharmaceutics, there are several studies on natural resources for finding rich sources of antioxidants and their role in protecting the body against oxidative stress injuries. The purpose of this study was to investigate the antioxidant stability of arbutin and the Pyrus boissieriana buhse Leaf extract and their effects on li...

Many plants are claimed to possess antidiabetic and antioxidant activity. In practice, it is being increasingly recognized to be an alternative approach to modern medicine. This study assess the antioxidant capacity of Tinospora cordifolia stem methanol extract in daily oral administration of 500 mg/kg of body weight for 40 days in alloxan induced diabetic rats. The erythrocytes membrane lipid ...

Objective: Diabetes is the most common metabolic disease. One of the most common problems in diabetic patients is atherosclerotic cardiovascular disease which induced by hyperlipidemia. Also there has been currently great interest in the potential contribution of oxidative stress in development of diabetes complications. The present study was performed to associate between lipid oxidizability a...

An experiment was conducted to investigate the effects of zinc application and salinity stress (0, 33, 66 and 99 mM NaCl) on some morphological and physiological parameters of soybean (Glycine max L., var. Williams). Results showed that zinc application improved shoot length, root fresh and dry weight and shoot fresh and dry weight under all salinity treatments. The catalase (CAT), ascorbate pe...

Induction of oxidative stress and possible involvement of antioxidants in rice (Oryza sativa L) leaves after in vivo treatment with hydrogen peroxide (H 2 O 2) was investigated. Degradation of chlorophyll, carotenoid and protein contents in rice leaves was observed which showed a recovery under free radical scavenger treatments. An increase in both total peroxide accumulation and lipid peroxida...

In the present study, Hibiscus rosasinensis polyphenol-rich extract (HPE) was isolated from the flowers and evaluated for its protective effect against hydrogen peroxide (H2O2) induced oxidation in normal human erythrocytes. RBCs pretreated with different concentrations of HPE extract showed the same hemolysis as that of control samples, demonstrating that the tested HPE extract did not have a ...

Reactive oxygen species can be generated by daily exposure of the skin to ultraviolet light and may cause some subchronic and chronic skin disorders. The aim of this study was to investigate a possible preventive role of alpha-tocopherol acetate (ATA) on ultraviolet B (UVB) induced peroxidation by assessing lipid peroxide (LPO) levels and activity of reactive oxygen scavenging enzymes including...

T HE livability of stored bull spermatozoa is decreased by aerobic agitation (Prince and Almquist, 1948). Hydrogen peroxide has been implicated in defects of motility, livability and metabolism in spermatozoa of various species (MacLeod, 1943; VanDemark et al., 1949; Tosic and Walton, 1950; Wales et al., 1959). Investigations not involving spermatozoa have demonstrated that exogenous hydrogen p...