In this paper, the system of Fredholm integral equations of the second kind is investigated by using a modified degenerate kernel  method (MDKM). To construct a MDKM the source function is approximated by the same way of producing degenerate kernel. The interpolation is used to make the needed approximations. Lagrange polynomials are adopted for the interpolation. The equivalency of  proposed m...

PURPOSE Investigate the role of metabolites in bioequivalence (BE) assessment. METHODS. Sets of ordinary differential equations are used to generate concentration - time data for both parent drug (P) and metabolite (M). The calculations include 24 subjects, two different formulations (Test, Reference), and a range of Test/Reference ratios for the fraction of dose absorbed and the rate of absorp...

In this paper we explore the labor market returns to the General Education Development exam, or GED, using data from the Current Population Survey. We examine how the return to the GED varies between natives in the U.S. and the foreign-born who received their formal education outside of the U.S. We find that the foreign-schooled with a GED earn statistically significantly higher wages than both...

To support the development of a fixed-dose combination (FDC) of ezetimibe and atorvastatin for the treatment of dyslipidemia, bioequivalence (BE) studies were conducted across a combined dose range (10/10, 10/20, 10/40, and 10/80 mg of ezetimibe/atorvastatin). In the BE trials, all parameters met traditional BE bounds except for atorvastatin peak plasma concentration (Cmax) at two intermediate ...

In this paper, we estimate GARCH, EGARCH, and GJR-GARCH models assuming normal and heavy-tailed distribution (i.e., GED). Results suggest that when the heavy-tailed distribution is considered, the persistence has found to be reduced in all the cases. Findings also reveal that positive shocks are more common than the negative shocks in this market.