Copper (Cu)-dependent lysyl oxidase (LO) catalyzes crosslinking of collagen and elastin stabilizing the extracellular matrix (ECM). Chronic inhalation of cadmium (Cd), a toxic metal, induces emphysema. To probe mechanisms of Cd injury to the lung, we developed Cd-resistant (CdR) cells from rat fetal lung fibroblasts (RFL6) by chronic exposure to CdCl(2) from 1 to 40 microM and further examined ...

All multipotent hematopoietic progenitors in C57BL-Thy-1.1 bone marrow are divided among three subpopulations of Thy-1.1(lo) Sca-1+ Lin(-/lo) c-kit+ cells: long-term reconstituting Mac-1- CD4- c-kit+ cells and transiently reconstituting Mac-1(lo) CD4- or Mac-1(lo) CD4(lo) cells. This study shows that the same populations, with similar functional activities, exist in mice whose hematopoietic sys...

Dreher escribe “La percepción psicoanalítica sin conceptos psicoanalíticos adecuados es ciega, los referencia a fenómenos relevantes están vacíos”, explicando que la investigación conceptual en psicoanálisis una cual se encuentran entrelazadas dimensión y empírica. Este escrito aborda el tema de analizabilidad por medio afinar especificidad del relación psicoterapia, considerar las fronteras lo...

Résumé. Depuis 2001, les conférences EGC ont rassemblé 1 782 chercheurs autour de l’extraction et la gestion de connaissances. En 2016, l’association EGC réfléchit à son histoire et se projette en lançant un défi à sa communauté. Que peut-on révéler sur la communauté EGC via des approches développées en EGC ? Notre étude lexico-scientométrique apporte un éclairage sur les thématiques du congrès...

We analyze three different sources of noise in a sampling mixer working at radio frequency (RF) or intermediate frequency. External RF and intrinsic noise are analyzed using conventional frequency domain methods. External local oscillator (LO) noise is analyzed in time domain by solving a stochastic differential equation. We are able to take into account the timevarying aspect of the LO noise c...

Lysyl oxidase (LO) catalyzes crosslinking of collagen and elastin essential for maintaining the structural integrity of the lung extracellular matrix (ECM). To understand mechanisms of cigarette smoke (CS)-induced emphysema, we investigated effects of cigarette smoke condensate (CSC), the particulate matter of CS, on LO mRNA expression in cultured rat fetal lung fibroblasts (RFL6). Exposure of ...

INTRODUCTION It was previously shown that lipoxygenase (LO) pathways are important in the rheumatoid arthritis (RA) inflammatory process and that synovial fluid from RA patients contains high amounts of leukotrienes. We therefore aimed to investigate the 5-LO and 15-LO-1 expression pattern in RA and ostheoarthritis (OA) synovial tissue and to study the effect of intraarticular glucocorticoid (G...

Leukotrienes (LTs) are lipid messengers generated by leukocytes that drive inflammation and modulate neighboring cell function. The synthesis of LTs from arachidonic acid is initiated by the enzyme 5-lipoxygenase (5-LO). We report for the first time that LT synthesis is inhibited by the direct action of protein kinase A (PKA) on 5-LO. The catalytic subunit of PKA directly phosphorylated 5-LO in...