aim: this study is aimed to elicit the possible correlation between breast and colon cancer from molecular prospectiveby analyzing and comparing pathway-based biomarkers.background: breast and colon cancer are known to be frequent causes of morbidity and mortality in men and womenaround the world. there is some evidence that while the incident of breast cancer in young women is high, it is repo...

objective: hypoxia-inducible factor (hif)-1 plays an essential role in the body’s response to low oxygen concentrations and regulates expression of several genes implicated in homeostasis, vascularization, anaerobic metabolism as well as immunological responses. increased levels of hif-1α are associated with increased proliferation and more aggressive breast tumor development. lactobacilli have...

objective(s):multidrug resistance (mdr) of cancer cells is a major obstacle to successful chemotherapy. overexpression of breast cancer resistance protein (bcrp) is one of the major causes of mdr. in addition, it has been shown that pi3k/akt signaling pathway involves in drug resistance. therefore, we evaluated the effects of novel approaches including sirna directed against bcrp and targeted t...

Introduction: Major depressive disorder is often associated with suicidal tendencies, and this condition accentuates the need for rapid-acting antidepressants. We previously reported that alkaloids (ALK) from Trichilia monadelpha possess antidepressant action in acute animal models of depression and that this effect is mediated through the monoamine and L-arginine-NO-cGMP pathways. This study i...

objective: infection with herpes simplex virus type 1 induces viral latency in neuron trigeminal ganglions. the late associated transcript (lat) is uniquely expressed in infected neural cells, however no coding protein associated with these transcripts has been identified in infected cells. it has been shown that six micrornas transcribed from lat have the capabilities to affect the cell signal...

average age distribution and generation interval were investigated in four different selection pathways. i.e., sire of future sires (ss), sire of future dams (sd), dam of future sires (ds) and dam of future dams (dd). young bulls pathway (yb) is also considered as a path that affects the generation interval in sd pathway when using progeny testing program. data were collected from animal breedi...