PURPOSE To compare the effect of vitamin K(2) and risedronate on trabecular bone in glucocorticoid (GC)-treated rats. MATERIALS AND METHODS Forty-eight Sprague-Dawley female rats, 3 months of age, were randomized by the stratified weight method into 5 groups according to the following treatment schedule: age-matched control, GC administration, and GC administration with concomitant administra...

AIM Spinal Cord Injury (SCI) is routinely treated with standardized methyl prednisolone sodium succinate (MPSS) dose, so it is reassuring to find its effects on liver. We also evaluated the effects of albumin and immunoglobulin G (Ig G) therapies on liver if they are used in case of experimental SCI. MATERIAL AND METHODS The rats were allocated into six groups as control, trauma, vehicle, MPS...

Introduction: Succinic acid, containing two equivalent carboxylic acid carbons, is a prime molecule for use in hyperpolarization studies. Hyperpolarized succinate has many potential uses as it has been implicated as a paracrine signal for liver damage [1] and succinate dehydrogenase (SDH) has been shown to be a tumor suppressor [2]. Mutations in the SDH enzyme lead to accumulation of intracellu...

Proximal tubule cells extract dicarboxylates from filtrate and blood, using cotransporters located in the brush border [sodium dicarboxylate cotransporter (NaDC-1)] and basolateral cell membrane (NaDC-3). We expressed the human NaDC-3 (hNaDC-3) in Xenopus laevis oocytes and characterized it by the two-electrode voltage-clamp technique. At -60 mV, succinate (4 carbons) and glutarate (5 carbons) ...

Azotobacter vinelandii strain ATCC 12837 and A. chroococcum strain H23 (CECT 4435) were able to grow on N-free or NH4Cl-amended chemically-defined (Burk's) media, with protocatechuic acid (1-2 mmol 1(-1)) or sodium p-hydroxybenzoate (1-10 mmol 1(-1)) as sole carbon (C) sources. At a concentration of 2 mmol 1(-1), both substrates supported nitrogen fixation (acetylene reduction assay) at similar...

Two simple, rapid and accurate conductometric methods were developed for determination of losartan potassium, pantoprazole sodium, sumatriptan succinate, rabeprazole sodium and lomefloxacine HCl in pure form as well as in their pharmaceutical formulations. The proposed methods based on using two different precipitating agents for conductometric determination of the cited drugs. Method (A) based...

In this study, the effects of some environmental storage conditions – light, temperature and humidity on the stability of the steroidal drug, hydrocortisone sodium succinate injection were investigated. The drug samples were stored at varying conditions of light, temperature (0C, 28C and 60C) and humidity, after which each sample was assayed at weekly intervals for their content of the drug usi...

INTRODUCTION: Endogenous succinate functions as a pro-inflammatory factor, while exogenous — an anti-inflammatory factor. The mechanisms of effect succinates on the inflammatory response are not fully understood. OBJECTIVE: Generalization current scientific knowledge use in inhibition response. MATERIALS AND METHODS: PubMed, Web Science, Google Scholar, Scopus, and eLibrary international databa...

Each mL of these preparations contains: Methylprednisolone acetate.............................. 20 mg Polyethylene glycol 3350....................................29.5 mg Polysorbate 80 ....................................................1.97 mg Monobasic sodium phosphate ..............................6.9 mg Dibasic sodium phosphate USP..........................1.44 mg Benzyl alcohol added as a...

Each mL of these preparations contains: Methylprednisolone acetate..................................20 mg Polyethylene glycol 3350.....................................29.5 mg Polysorbate 80 .....................................................1.97 mg Monobasic sodium phosphate ...............................6.9 mg Dibasic sodium phosphate USP...........................1.44 mg Benzyl alcohol add...