recent studies in animal models indicate that recombinant human erythropoietin (rhepo) is very effective in enhancing neurological recovery after spinal cord injury (sci). we aimed to evaluate the effect of rhepo plus methylprednisolone sodium succinate (mpss) compared to mpss alone to improve neurological function of patients after sci in a randomized clinical trial. during a 15-month period 3...

Methylprednisolone sodium succinate (50 mg/kg) was given 30 minutes before or after the start of a 90 minute occlusion of the left circumflex coronary artery (LCX) in one group of dogs. In a second group, methylprednisolone sodium succinate was given 15 minutes after permanent occlusion of the left anterior descending artery (LAD). Infarct size was determined by dehydrogenase staining after 24 ...

In this work behavior of active pharmaceutical substances  methylprednisolone (in a form of methylprednisolone sodium succinate) in finished pharmaceutical dosage form – freeze dried powder for injections was examined. The goal was to evaluate the chemical stabilities of methylprednisolone sodium succinate packaged in dual chamber vial, as a specific container closure system. The effect of dif...

Dr. R. Peces, Servicio de Nefrologia, Hospital Covadonga, Celestino Villamil s/n, E-33006 Oviedo (Spain) Dear Sir, Intravenous methylprednisolone is currently used before transplantation as well as for the treatment of acute rejection episodes. Hypersensitivity to methylprednisolone is extremely rare and the reported cases were mostly in atopic or asthmatic patients [1–7]. Among them, only 2 ca...

Previous studies on transgenic mice indicate that upregulation of utrophin protein may offer a potential treatment strategy for Duchenne muscular dystrophy. We have analyzed the effect of the glucocorticoid 6a-methylprednisolone-21 sodium succinate on utrophin protein levels using a cell-based assay with differentiated human myotubes derived from biopsies of healthy individuals or Duchenne musc...

The increases in oxidation of glucose-1-(14)C and glucose-6-(14)C in BCG-sensitized alveolar macrophages are inhibited by administration of methylprednisolone sodium succinate. Both resting and phagocytizing cells are affected.

BACKGROUND Despite their frequent use, systemic corticosteroids have rarely elicited immediate-type reactions. OBJECTIVE We report two male patients, aged 26 and 70 years, respectively, with severe immediate-type hypersensitivity secondary to the administration of corticosteroids esterified with succinate. METHODS Skin tests, basophil activation tests and challenge tests were performed for ...

Purpose: The aim of this study was to examine the protective effects of nonsteroid anti-inflammatory drugs (NSAIDs) and steroids on seroma formation after mastectomy and axillary lymph node dissection in rats. Methods: Mastectomy and axillary lymph node dissection were applied to the rats. Thirty rats enrolled in the study were randomly divided into three groups of 10 each. Group I patients rec...