The loss of expression of the enzyme O6-methylguanine-DNA methyltransferase (the Mex- phenotype), which often results from cellular transformation, confers hypersensitivity to alkylating agents. We have observed two unrelated examples in which human cell lines have undergone a spontaneous alteration in their Mex phenotype during propagation in vitro. The change was reversible and was not the re...

RNA-binding E3 ubiquitin ligases were recently identified, though their function remains unclear. While studying the regulation of the MHC class I (MHC-I) pathway, we here characterize a novel role for ubiquitin in mRNA degradation. MHC-I molecules provide ligands for both cytotoxic T-lymphocytes as well as natural killer (NK) cells, and play a central role in innate and adaptive immunity. MHC-...

Complete planning and scheduling of all spacecraft operations is a challenging area with the remote agent experiment at Deep Space 1 being a pioneering system. Still the complete approach is rare in practice. For example, in the Mars Express (MEX) mission, planning and scheduling techniques are used to solve some subproblems namely scheduling command upload and data download. In this paper we d...

An adaptive threshold with constant false alarm rate (CFAR) property is proposed to be used in a channelized electronic support measures (ESM) system with logarithmic video ampli'cation. For this purpose, two CFAR processors are designed which are in fact modi'ed excision (MEx) and adaptive MEx (AMEx) processors, previously presented by authors, but modi'ed for the logarithmic ampli'cation case...

RNA granules are non-membrane bound cellular compartments that contain RNA and RNA binding proteins. The molecular mechanisms that regulate the spatial distribution of RNA granules in cells are poorly understood. During polarization of the C. elegans zygote, germline RNA granules, called P granules, assemble preferentially in the posterior cytoplasm. We present evidence that P granule asymmetry...

Mas, J.F. et al. have submitted a paper [1] for publication, which aims to respond to a paper published by Gebhardt et al. [2]. Mas, J.F. et al. had received a consultancy in 2013 to assess the quality of the early prototype products partly described in Gebhardt et al. in 2014. This consultancy, although a formal non-disclosure agreement had not been demanded, was awarded under the mutual under...

The mechanism of inactivation of the O6-methylguanine-DNA methyltransferase (MGMT), responsible for repair of mutagenic and cytotoxic O6-alkylguanine, in Mex- tumor cells, is not completely understood. We have examined the role of CpG methylation in the human MGMT promoter in a luciferase (luc) reporter plasmid and associated alteration in chromatin structure. Methylation of 16% CpG sequences i...

A semi-visual framework for the speci cation of syntax and semantics of imperative programming languages, called Montages, was proposed in an earlier work by the authors. The primary aim of this formalism is to assist in recording the decisions taken by the designer during the language design process. The associated tool Gem-Mex allows the designer to maintain the speci cation and to inspect th...

In the present paper, a methodology is presented which enables the implementation of the Action Notation formalism based on a formal and modular specification. As a result, an interpreter and debugger is automatically generated which allows the visualization of an Action Notation program execution and the inspection of all semantic identities in terms of the given formal specification. These re...