background and purpose: medical professional behavior includes the characteristics of devotion, integrity, compassion, good communication skills, respect, responsibility, excellence and leadership. evaluation plays an important role in identifying the professionalism of people and training. thus, this study was conducted to evaluate the professional behavior of clinical residents. methods: in t...

Solving the science data downlink problem for Mars Express (MEX) has been a challenge. An artificial intelligence (AI) based tool, MEXAR2, has been developed and integrated in the mission planning process that allows the user to quickly and effortlessly generate and analyse a dump plan for any planning period. MEXAR2 is the first AI-based tool in an operational environment on-ground at ESOC and...

introduction: teaching medical professionalism is increasingly acknowledged as an important aspect of medical education. the professionalism mini-evaluation exercise (p-mex) is an assessment tool for evaluating medical professionalism, but no studies using it as a self-assessment instrument have been reported. this paper reports on a preliminary investigation of the finnish version of the p-mex...

Introduction: Teaching medical professionalism is increasinglyacknowledged as an important aspect of medical education.The Professionalism Mini-Evaluation Exercise (P-MEX) is anassessment tool for evaluating medical professionalism, butno studies using it as a self-assessment instrument have beenreported. This paper reports on a preliminary investigation of theFinnish version of the P-MEX instr...

Polo kinases are known key regulators of cell divisions. Here we report a novel, non-cell division function for polo kinases in embryonic polarity of newly fertilized Caenorhabditis elegans embryos. We show that polo kinases, via their polo box domains, bind to and regulate the activity of two key polarity proteins, MEX-5 and MEX-6. These polo kinases are asymmetrically localized along the ante...

INTRODUCTION Teaching medical professionalism is increasingly acknowledged as an important aspect of medical education. The Professionalism Mini-Evaluation Exercise (P-MEX) is an assessment tool for evaluating medical professionalism, but no studies using it as a self-assessment instrument have been reported. This paper reports on a preliminary investigation of the Finnish version of the P-MEX ...

In the present study, we report the identification and characterization of MEX (MEKK1-related protein X), a protein with homology to MEKK1 that is expressed uniquely in the testis. MEX is comprises four putative zinc-binding domains including an N-terminal SWIM (SWI2/SNF2 and MuDR) domain of unknown function and two RING (really interesting new gene) fingers separated by a ZZ zinc finger domain...

Totipotent stem cells have the potential to differentiate into every cell type. Renewal of totipotent stem cells in the germline and cellular differentiation during early embryogenesis rely upon posttranscriptional regulatory mechanisms. The Caenorhabditis elegans RNA binding protein, MEX-3, plays a key role in both processes. MEX-3 is a maternally-supplied factor that controls the RNA metaboli...

BACKGROUND Mexiletine (Mex) has been proposed as a gene-specific therapy for patients with long-QT syndrome type 3 (LQT3) caused by mutations in the cardiac sodium channel gene (SCN5A). The degree of QT shortening and the protection from arrhythmias vary among patients harboring different mutations. We tested whether the clinical response to Mex in LQT3 could be predicted by the biophysical pro...

The efficacy and mechanism of protection of a new 2,2,5, 5-tetramethylpyrroline derivative of mexiletine, MEX-NH, against ischemia/reperfusion-induced cardiac dysfunction are reported. The MEX-NH and its nitroxide metabolite are membrane-permeable antioxidants. Studies were performed in an isolated rat heart model to measure the efficacy of MEX-NH in preventing postischemic injury. Serial measu...