Background and Aim: Chronic myelogenous leukemia is characterized by Philadelphia (Ph) chromosome, the presence of BCR-ABL fusion gene and constitutive activation of the ABL1 tyrosine kinase. Despite an excellent result of target therapy by imatinib, some patients develop resistance to imatinib. In this study Efficacy of HESA-A on proliferation and apoptosis of K562 cell line was assessed. Mat...

Background and purpose: Different methods such as surgery, chemotherapy, radiotherapy, hormone therapy and immunotherapy are used for treatment of melanoma cancer. Unfortunately they don't always have desirable results and they may have unfavorable side effects. Researchers try to find new, more effective drugs with low side effects. In this study we evaluated the cytotoxic effect of ACA-1, a...

Background: Ewing's sarcoma is one of the most malignant tumors in children and young adults. Only a few established cell lines of Ewing's sarcoma have been reported, which makes it difficult to study the biological features of these tumors. We have recently established a new Ewing's sarcoma cell line designated SS-ES-1, originating from a thoracic tumor of a 16-year-old female patient. The SS-...

Background: Every year thousands of people die because of stomach cancer and brain tumors. N. sativa plant has thymoquinone and this compound may prevent cancer cell line growth in many types of cancer. The purpose of this study was to examine the possibility of inhibiting cell growth in human stomach gastric adenocarcinoma (AGS) and astrocytoma cell lines (AST) by N. sativa and N. arvensis ext...