background: intravenous valproate (ivvp) has been used in the treatment of migraine in some studies; however, it is far better known in the management of status epilepticus. methods: consecutive patients with migraine in our headache clinic were enrolled in this prospective, randomized clinical trial in 2011. the patients were randomized into two therapeutic groups, one receiving 900 mg ivvp (o...

The effect of acute migraine attack and rectally given metoclopramide on the absorption of orally given tolfenamic acid (300 mg) was investigated in seven female patients in a crossover study consisting of four phases, two without migraine and two during migraine. Metoclopramide hydrochloride (20 mg) or placebo was given double-blind. Migraine attacks delayed the absorption of tolfenamic acid. ...

conclusions headaches, particularly migraine without aura, are a common occurrence in pregnancy in our population. migraine severity is positively associated with high blood glucose levels. results the headache prevalence during pregnancy was 69% in the women with diabetes and 64% in the women without diabetes. a positive unilateral distribution was observed in 51% of the cases and 36.3% of the...

BACKGROUND AND PURPOSE Transcatheter closure of patent foramen ovale (PFO) has been reported to improve migraine in patients with cerebrovascular disorders in noncontrolled studies. The aim of the study was to compare the course of migraine assessed prospectively over a 12-month period in symptomatic (for cerebrovascular disease) and asymptomatic patients undergoing PFO closure and in patients ...

Posttraumatic migraine may represent an important subtype of headache among the traumatic brain injury (TBI) population and is associated with increased recovery times. However, it is underdiagnosed in patients with mild traumatic brain injury (mTBI). This study examined the effectiveness of the self-administered Nine-Item Screener (Nine-Item Screener-SA), the Headache Impact Test- 6 (HIT-6), t...

BACKGROUND Migraine often occurs during weekends. The efficacy of frovatriptan, naproxen sodium, or no therapy for the acute or prophylactic treatment of weekend migraineurs was tested in an open-label, nonrandomized pilot study. METHODS Twenty-eight subjects (mean age 36 ± 12 years, including 18 females) suffering from migraine without aura were followed up for six consecutive weekends. No t...

OBJECTIVE Migraine is the most common acute intermittent primary headache in children and prophylactic therapy is indicated in children with frequent or disabling headaches. The purpose of this study was to evaluate the efficacy and safety of topiramate (TPM) for migraine prophylaxis in children. MATERIALS & METHODS In a quasi-experimental study, monthly frequency, severity and duration of he...

OBJECTIVE To study the efficacy and practicality of treating headache in professional footballers with intranasal sumatriptan. METHODS An open label drug trial was performed in elite Australian footballers using intranasal sumatriptan (20 mg) treatment for acute headache. The main outcome measures were treatment response at 30 minutes, two hours, and 24 hours using two criteria: (a) initial s...

Migraine is a common chronic neurological disease characterized by episodic attacks of headache and associated symptoms. The pharmacological treatment of migraine may be acute or prophylactic, and patients with frequent, severe headaches often require both approaches. Prophylactic treatment is used to reduce the frequency, duration, or severity of attacks, to enhance the benefits of acute treat...

The important developments in our understanding and harnessing the biology of migraine have not diminished the need to consider the psychology of migraine. Psychological treatments especially relaxation training and biofeedback have been well validated as effective in treating frequent migraine. When the frequency and severity of migraine warrants more than analgesics, these treatments are the ...