Previous studies have shown that mithramycin A (MIT) is a promising candidate for the treatment of pancreatic carcinoma through inhibiting transcription factor Sp1. However, systemic toxicities may limit its clinical application. Here, we report a rationally designed formulation of MIT-loaded nanoparticles (MIT-NPs) with a small size and sustained release for improved passive targeting and enha...

Personnel involved: Prof. Jack B. Howard, PI. Department of Chemical Engineering, MIT Dr. Henning Richter, Research Associate, Department of Chemical Engineering, MIT Murray J. Height, Graduate Student, Department of Chemical Engineering, MIT Timothy G. Benish, Graduate Student, Department of Chemical Engineering, MIT Dr. Peter Hebgen, Postdoctoral Associate, Department of Chemical Engineering,...

We introduce the notion of mIT -structures determined by operators mInt and mCl on an m-space (X,mX). By using mIT -structures, we introduce and investigate a function f : (X,mIT ) → (Y,mY ) called MIT -continuous. As special cases of MIT -continuity, we obtain M -semicontinuity [21] and M -precontinuity [23].

designing an effective criterion for selecting the best rule is a major problem in theprocess of implementing fuzzy learning classifier (flc) systems. conventionally confidenceand support or combined measures of these are used as criteria for fuzzy rule evaluation. in thispaper new entities namely precision and recall from the field of information retrieval (ir)systems is adapted as alternative...

Mitoxantrone (MIT) is a chemotherapeutic agent with promising anticancer efficacy. In this study, Pluronic F68-vitamine E succinate (F68-VES) amphiphilic polymer micelles were developed for delivering MIT and enhancing its anticancer activity. MIT-loaded F68-VES (F68-VES/MIT) micelles were prepared via the solvent evaporation method with self-assembly under aqueous conditions. F68-VES/MIT micel...

Strengthening of existing circular reinforced concrete columns by CFRP confinement

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