نتایج جستجو برای: mito mycin c

تعداد نتایج: 1059857  

2011
Suzanne Hoppins Sean R. Collins Ann Cassidy-Stone Eric Hummel Rachel M. DeVay Laura L. Lackner Benedikt Westermann Maya Schuldiner Jonathan S. Weissman Jodi Nunnari

To broadly explore mitochondrial structure and function as well as the communication of mitochondria with other cellular pathways, we constructed a quantitative, high-density genetic interaction map (the MITO-MAP) in Saccharomyces cerevisiae. The MITO-MAP provides a comprehensive view of mitochondrial function including insights into the activity of uncharacterized mitochondrial proteins and th...

2012
Jaime Santo-Domingo Nicolas Demaurex

The generation of a proton gradient across the inner mitochondrial membrane (IMM) is an essential energy conservation event that couples the oxidation of carbohydrates and fat to the synthesis of ATP. Studies in isolated mitochondria have established that the chemical gradient for protons (pH m) and the mitochondrial membrane potential ( m) contribute independently to the proton-motive force...

Journal: :Cancer research 2005
Shanbao Cai Yi Xu Ryan J Cooper Michael J Ferkowicz Jennifer R Hartwell Karen E Pollok Mark R Kelley

DNA repair capacity of eukaryotic cells has been studied extensively in recent years. Mammalian cells have been engineered to overexpress recombinant nuclear DNA repair proteins from ectopic genes to assess the impact of increased DNA repair capacity on genome stability. This approach has been used in this study to specifically target O(6)-methylguanine DNA methyltransferase (MGMT) to the mitoc...

Journal: :Journal of the American Society of Nephrology : JASN 2001
C A Davis H S Nick A Agarwal

Cisplatin is a potent chemotherapeutic agent that is used to treat many human malignancies. Unfortunately, in addition to side effects such as ototoxicity, anaphylaxis, and bone marrow suppression, a significant percentage of patients receiving cisplatin develop severe nephrotoxicity. Mitochondrial dysfunction that is mediated via the generation of reactive oxygen species has been implicated in...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Alicia M Pickrell Milena Pinto Aline Hida Carlos T Moraes

Parkinson's disease (PD) is one of the most common progressive neurodegenerative disorders, characterized by resting tremor, rigidity, bradykinesia, and postural instability. These symptoms are associated with massive loss of tyrosine hydroxylase-positive neurons in the substantia nigra (SN) causing an estimated 70-80% depletion of dopamine (DA) in the striatum, where their projections are loca...

2005
William van Melle Edward H. Shortliffe Bruce G. Buchanan

Much current work in artificial intelligence focuses on computer programs that aid scientists with complex reasoning tasks. Recent work has indicated that one key to the creatior~:..@f intelligent systems is the incorporation of large amounts of task-specific knowledge. Building knowledge-based, or expert, systems from scratch can be very time-consuming, however. This suggests the need for gene...

Journal: :American journal of physiology. Cell physiology 2007
Johannes H G M van Beek

Computational models of a large metabolic system can be assembled from modules that represent a biological function emerging from interaction of a small subset of molecules. A "skeleton model" is tested here for a module that regulates the first phase of dynamic adaptation of oxidative phosphorylation (OxPhos) to demand in heart muscle cells. The model contains only diffusion, mitochondrial out...

1985
Didier Dubois Henri Prade

The behavior of Dempster's rule of combination in typical situations is examined. Particularly, it is shown that assessing a zero value or a very small value may lead to very different results. Moreover a comparison with a possibility theory-based approach in case of conf l ict ing information is provided. The general problem of representing uncertainty with one or several numbers is addressed....

2013
Takayuki Mito Yoshiaki Kikkawa Akinori Shimizu Osamu Hashizume Shun Katada Hirotake Imanishi Azusa Ota Yukina Kato Kazuto Nakada Jun-Ichi Hayashi

Mitochondrial DNA (mtDNA) mutator mice are proposed to express premature aging phenotypes including kyphosis and hair loss (alopecia) due to their carrying a nuclear-encoded mtDNA polymerase with a defective proofreading function, which causes accelerated accumulation of random mutations in mtDNA, resulting in expression of respiration defects. On the contrary, transmitochondrial mito-miceΔ car...

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