background and objectives: tetanus and diphtheria are vaccine-preventable, infectious diseases with significant morbidity and mortality. immunization by the diphtheria and tetanus toxoid (dt) has been applied in iran for almost 50 years. however, there are very few data about the rate of immunity to these diseases in the adult population. the humoral immunity to tetanus and diphtheria among blo...

purpose: to evaluate the vascular occlusion in coats’ disease   methods: in this non-comparative case series, 13 consecutive patients with coats’ disease from january 2011 to september 2011 were included. the hypercoagulability states were evaluated in these patients.   results: the mean age of the patients in this series was 15.4 years. all but one patient had high anti-cytomegalovirus antibod...

conclusions the r-b-flagellin carried antigenic epitopes just like the native flagellin, while the polyclonal antibody raised against it exhibited functional activity. results the polyclonal antibodies raised against this r-b-flagellin inhibited the motility of the homologous pao1 strain of p. aeruginosa, which significantly decreased the invasion of the pao1 strain into the a549 cells and also...

background: allergens are mostly composed of glycoprotein structures. it is believed that glycan-specific antibodies may lead to false-positive reactions in immunoassays. in this study we investigated the glycosylation state of grape allergens as well as the presence of antibodies to cross-reactive carbohydrate determinants (anti-ccds) in sera from grape-sensitive individuals. methods: grape ex...

the rotavirus nonstructural protein 4 (nsp4), is a multi functional protein that play key role in both viral morphogenesis and cytopathic effect associated with cell death. however, the complete biological effect of nsp4 remains to be clarified. since to obtain further knowledge about this protein there is a need for recognizing antibody and there is no commercial antibody against this protein...

an indirect enzyme–linked immunosorbent assay (elisa) was developed for screening of antibody to avian infectious bronchitis virus (ibv). antigen was prepared from whole-purified ibv massachusetts serotype (br 801 strain). optimum dilution with minimum background for antigen concentration, rabbit anti-chicken conjugate and sera in developed elisa was determined 0.1μg/ml, 1:3000 and 1:100, respe...

Understanding the physicochemical properties of antibody–drug conjugates is critical to assess their quality at manufacturing and monitor them during subsequent storage. For radiometal–antibody complexes, it important control antibody–chelator conjugate maintain final product. We have been developing 64Cu-labeled anti-epidermal growth factor receptor antibody NCAB001 (64Cu-NCAB001) for early di...

Foot and mouth disease (FMD) is a contagious animal disease that causes irreparable damage to the economy of countries, including Iran in which this disease is a native one. Among the ways to combat FMD are vaccination and slaughter. Due to the specific situation of Iran, it is not possible to kill infected animals. Therefore, vaccination is the most important way to fight this disease. S...

background: decay of vaccine–induced antibody titres without boosting of the wild measles virus has been well documented. revaccination against measles has reduced the prevalence of the disease worldwide. revaccination may cause ige induced anaphylaxis. objective: to study measles igg antibody in revaccinated populations and its relation to ige induced hypersensitivity. methods: blood samples w...