objective(s): in the past few decades, variety of foetal, embryonic and adult stem and progenitor cells have been tried with conflicting outcome for cell therapy of central nervous system injury and diseases. cellular characteristics and functional plasticity of globose basal stem cells (gbcs) residing in the olfactory epithelium of rat olfactory mucosa have not been studied in the past by the ...

Adult neurogenesis is a process of producing nerve cells from their progenitor that occurs in some areas in the brain such as the hypothalamus. Low activity in this area plays a role in neural degeneration and diseases such as multiple sclerosis, epilepsy and depression. MS is a neurodegenerative disease with a permanent disability that the main reason for it is axonal degeneration and neuronal...

the effect and arrangement of cytoskeleton (microtubules, microfilaments and neurofilaments) in neurulation of chick embryo examined by immunoperoxidase method from stage 6 to stage 12. the results were as follows: 1) microtubules aggregated in the perinuclear region from which they radiated to take longitudinal course beneath the membrane. 2) microfilaments were aggregated in the apical ends (...

Multiple sclerosis (MS) is one of the most common neuroinflammatory disorders that causes disability in the young adults. In this disease immune-driven demyelination and following that inefficient remyelination occurs. Therapies for this disease are limited, especially those to enhance myelin repair. Cellular reprogramming using defined genetic factors is a way to produce remyelinating Oligoden...

Introduction: The aim of this study was evaluate the ability of notochord to induce neural induction and/or differentiation of mouse embryonic stem cell to neuron and motor neuron, respectively. Methods: In order to produce embryoid bodies, ES cells line Royan B1 were grown in suspension in the absence of LIF for 4 days. EBs were divided into 4 groups. EBs in group 1 & 2 were further cultur...

peroxisomes are small size organelles in nearly all eukaryotic cells involved in various metabolic functions including β-oxidation of very long chain fatty acids and metabolite peroxidation and plasmalogens synthesis. the latter is one of the major constituents in neural cell membranes. the biogenesis of peroxisomes is a complex process which requires multiple proteins encoded by pex genes. dys...

objective: cd133+ umbilical cord blood cells were identified as a hematopoietic stem cell which has the capacity for extensive self-renewal and differentiation. the aim of this study was to identify the effect of staurosporine (sts), a wellknown protein kinase inhibitor on differentiation of cd133+ cells into neural cells. materials and methods: cd133+ cells were enriched by immunomagnetic bead...