Idiopathic Parkinson’s disease (PD) is a neurodegenerative disorder and the most common cause of the Parkinsonian syndrome: asymmetric bradykinesia, hypokinesia, and rigidity, sometimes combined with rest tremor and postural changes. Historically, PD treatment has primarily aimed to replace the loss of dopamine through pharmaceutical intervention, which may reduce physical symptoms and slow pro...

Inhibitory and excitatory synapses play a fundamental role in information processing in the brain. Excitatory synapses usually are situated on dendritic spines, small membrane protrusions that harbor glutamate receptors and postsynaptic density components and help transmit electrical signals. In recent years, it has become evident that spine morphology is intimately linked to synapse function--...

UNLABELLED Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals and neurologic manifestations may be one of the presentations form. The aim of this study was to report the incidence of neurologic manifestations in children with CD. MATERIAL AND METHODS Between 2000-2010, 48 children aged 2-18 years diagnosed with CD ...

OBJECTIVE To report neurologic phenotypes and their etiologies determined among 68 patients with either (1) celiac disease (CD) or (2) no CD, but gliadin antibody positivity (2002-2012). METHODS Neurologic patients included both those with the CD-prerequisite major histocompatibility complex class II human leukocyte antigen (HLA)-DQ2/DQ8 haplotype, and those without. The 3 groups were as foll...

a retrospective analysis of associated variables. Chest 1993; 103:1646-50 3 Wittnich C, Trudel J, Zidulka A, Chiu RC-J. Misleading "pulmonary wedge pressure" after pneumonectomy: its importance in postoperative fluid therapy. Ann Thorac Surg 1986; 42:192-96 4 Cohen E, Neustein SM, Kirschner PA. Inadvertent transection of a pulmonary artery catheter during thoracic surgery. J Cardiothorac Vasc A...

Circular RNAs (circRNAs) are a novel type of endogenous noncoding RNA receiving increasing attention. They have been shown to act as a natural microRNA sponges that repress the activity of corresponding miRNAs by binding with them, thus regulating target genes. Numerous studies have shown that miRNAs are involved in the pathogenesis of neurological diseases. Therefore, circRNAs may act as impor...

RNA has greater complexity than DNA. RNA folds into complex shapes, utilizing both sequence and structure, allowing it to harbor both information content and enzymatic activity. From a single DNA template, RNA can offer combinatorial complexity (via alternative splicing of exons or RNA editing), as well as the ability to regulate protein expression in space and time (Darnell 2002). Given the ne...

I n recent years substantial advances have taken place in understanding the mechanistic pathways mediating neuronal cell death in a variety of neurologic diseases. Since the central nervous system (CNS) has little, if any, power of functional neuronal regeneration, prevention of neuronal cell death is an important target of modern neurotherapeutics. A detailed understanding of the mechanisms me...

OBJECTIVE To describe the incidence and nature of neurologic complications following liver transplantation. METHODS Adult patients who received liver transplants at St. James's University Hospital between September 1, 1990, and August 31, 2000, were identified. Case notes were reviewed and demographic data, details of the liver disease, neurologic complications, and discharge information were...