The neuromuscular effects of halothane, suxamethonium, and tubocurarine were observed in a female patient undergoing thymectomy because of myasthenia cUnically localized to extraocular muscles. The twitch response was compared with that obtained in a control group of five non-myasthenic patients. In the control non-myasthenic group, halothane 2 per cent increased the twitch response, suxamethon...

Stiff-person syndrome (SPS) is a neurologic disorder characterized by painful involuntary episodes of severe muscle rigidity affecting the axial muscles and extremities. Although the etiology of SPS is unknown, it is suspected to involve the synthesis of γ-aminobutyric acid (GABA). Symptoms of SPS are precipitated by sudden unexpected movements, noises, and stress. Additionally, SPS has been li...

SUGAMMADEX IS BELONGING TO A NEW CLASS OF DRUGS the selective relaxant binding agents. Sugammadex can reverse residual paralysis by encapsulating free circulating non depolarizing muscle relaxants. The mains advantages of sugammadex when compared with conventional anticholinesterase agents are a much faster recovery time and the unique ability, for the first time, to reverse rapidly and efficie...

SEVERAL studies have documented that neuromuscular block often persists in the postanesthesia care unit (PACU), even with the administration of acetylcholinesterase inhibitors. The frequency of this phenomenon, which has been called “residual curarization,” “residual neuromuscular block,” “postoperative residual curarization,” or “residual paralysis,” ranges between 4 and 50% depending on the d...

The effect of temperature on the potencies of neuromuscular blocking agents remains unclear. This study was undertaken to examine the effects of different neuromuscular blocking agents at 37 and 27 degrees C at a constant carbon dioxide content (alpha stat principle). The effect of neostigmine 1 mumol litre-1 induced antagonism of these agents was also investigated. Phrenic nerve-hemidiaphragm ...

Although neuromuscular blocking agents (NMBAs) provide optimal surgical conditions and a reduced incidence of laryngopharyngeal lesions during tracheal intubation, there are evidence of delayed paralysis and higher morbidity and mortality after their use. To date many anesthesiologists do not routinely use objective method to monitor neuromuscular function due to the fact that there are no idea...

During the perioperative period, anaphylactic reactions rarely occur. Neuromuscular blocking agents (NMBAs) are responsible for 60-70% of perioperative anaphylactic reactions. This case, we report a case of rocuronium-induced anaphylaxis in a 3-year-old girl with no previous exposure to NMBAs. This case cautions and informs practitioners that an IgE-mediated anaphylactic reaction with rocuroniu...