background and objective: hyperalgesia is one of the marked clinical signs of patients with diabetes mellitus that affects their lifestyle. this study was conducted to assess the anti-nociceptive effect of chronic administration of curcumin in streptozotocin (stz)-diabetic rats using formalin, hot tail immersion, and paw pressure tests. materials and methods: this study was conducted on 40 male...

Chalcone (1,3-diarylprop-2-en-1-one) derivatives have been introduced as selective cyclooxygenase-2 inhibitors. In the present study, anti-nociceptive and anti-inflammatory effects of eight novel compounds were evaluated in male mice and Wistar rats by using the writhing and formalin-induced paw edema tests respectively. The activities of the compounds were compared with celecoxib as a referenc...

Background: Teucrium polium has been known as an important traditional medicinal plant and is used for different therapeutic purposes such as gastrointestinal disorders. Therefore, the anti-spasmodic and antinociceptive activities of aqueous extract of Teucrium polium w as examined. Methods: Anti-spasmodic effect of different concentrations (47-470 mg/l) of Teucrium polium extract was assessed ...

Apple Cider Vinegar (ACV) is a natural compound that is used mainly in numerous food preparations. During the last few decades, ACV has been used for various therapeutic purposes in different countries. One of its main applications by people in Iran and other countries has been as an oral traditional remedy to control chronic pain in arthritis. In this study, ACV’s effects on acute and chronic ...

Acetylcholine and cholinomimetic agents with predominant muscarinic action are known to increase the concentration of cGMP by activation of nitric oxide signaling pathway in the nociceptive conditions. The present study was aimed to investigate the NO-cGMP-PDE5 pathway in nociceptive conditions in the experimental animals. Nociceptive threshold was assessed by acetic acid-induced writhing assay...

a b s t r a c t introduction: aloe vera extract is used as an anti-inflammatory and anti-bradikinin agent in laboratory animals. the aim of this survey was to evaluate the ant-nociceptive effect of a. vera aqueous extract in fructose-fed male rats. methods: forty-five wistar-albino male rats were equally and randomly divided into five groups including sham operated and four test groups. sham op...

fruits of olea europaea l. have been used for centuries in folk medicine to treat many inflammatory diseases. in order to evaluate the anti-nociceptive activities of the methanolic and aqueous extracts of defatted fruits of o. europaea, formalin test was used and for evaluation of anti-inflammatory effects of the extract, the volume of paw edema was measured. the results revealed that both extr...

introduction: glabrous skin and hairy skin are innervated by different types of noxious fibers. however, the different nociceptive behaviors induced by formalin, a commonly used model of acute inflammatory pain, have not yet been systematically examined in the glabrous and hairy skin. methods: in this study, we compared nociceptive behaviors induced by formalin injections (2%, 4%, and 8%) into ...

In this study, we focused on the neuro-behavioral profile, toxicity, and ‎possible mechanisms of action of ‎ Dorema ammoniacum gum essential oil (DAG-EO). For this purpose, passive avoidance and Y-maze tests were performed to evaluate the potential effect ‎of DAG-EO in the attenuation of memory impairment induced by 49 days administration of D-‎galactose and acute injection of scopolam...

Electrical stimulation of the skin using a needle-electrode specifically activates nociceptive nerve fibres. The detection of such stimuli by subjects depends on the activation of subsequent nociceptive mechanisms. Activation of these mechanisms depends on the temporal stimulus properties, such as the pulse-width, number of pulses, and inter-pulse interval. This different activation of nocicept...