Mehrdad Faizi

[ 1 ] - Study of Sedative-Hypnotic Effects of Aloe vera L. Aqueous Extract through Behavioral Evaluations and EEG Recording in Rats

In the present work sedative and hypnotic effects of aqueous extract of Aloe vera in rats have been investigated. In order to evaluate the overall hypnotic effects of the Aloe vera extract, open field and loss of righting reflex tests were primarily used. The sedative and hypnotic effects of the extract were then confirmed by detection of remarkable raise in the total sleeping time through anal...

[ 2 ] - Evaluation of Anti-Inflammatory and Anti-Nociceptive Effects of Defatted Fruit Extract of Olea europaea

Fruits of Olea europaea L. have been used for centuries in folk medicine to treat many inflammatory diseases. In order to evaluate the anti-nociceptive activities of the methanolic and aqueous extracts of defatted fruits of O. europaea, formalin test was used and for evaluation of anti-inflammatory effects of the extract, the volume of paw edema was measured. The results revealed that both extr...

[ 3 ] - Evaluation of Anti-nociceptive and Anti-inflammatory Activities of Novel Chalcone Derivatives

Chalcone (1,3-diarylprop-2-en-1-one) derivatives have been introduced as selective cyclooxygenase-2 inhibitors. In the present study, anti-nociceptive and anti-inflammatory effects of eight novel compounds were evaluated in male mice and Wistar rats by using the writhing and formalin-induced paw edema tests respectively. The activities of the compounds were compared with celecoxib as a referenc...

[ 4 ] - Design, Synthesis and Pharmacological Evaluation of Novel 2-[2-(2-Chlorophenoxy) phenyl]-1,3,4-oxadiazole Derivatives as Benzodiazepine Receptor Agonists

New derivatives of 2-[2-(2-Chlorophenoxy)phenyl]-1,3,4-oxadiazole as candidates for agonistic effect on benzodiazepine receptors were synthesized. Conformational analysis and superimposition of energy minima conformers of the novel compounds on estazolam, a known benzodiazepine agonist, revealed that the main proposed benzodiazepine pharmacophores were well matched. In pharmacological eval...

[ 5 ] - Study of Sedative-Hypnotic Effects of Aloe vera L. Aqueous Extract through Behavioral Evaluations and EEG Recording in Rats

In the present work sedative and hypnotic effects of aqueous extract of Aloe vera in rats have been investigated. In order to evaluate the overall hypnotic effects of the Aloe vera extract, open field and loss of righting reflex tests were primarily used. The sedative and hypnotic effects of the extract were then confirmed by detection of remarkable raise in the total sleeping time through anal...

[ 6 ] - Evaluation of Anti-Inflammatory and Anti-Nociceptive Effects of Defatted Fruit Extract of Olea europaea

Fruits of Olea europaea L. have been used for centuries in folk medicine to treat many inflammatory diseases. In order to evaluate the anti-nociceptive activities of the methanolic and aqueous extracts of defatted fruits of O. europaea, formalin test was used and for evaluation of anti-inflammatory effects of the extract, the volume of paw edema was measured. The results revealed that both extr...

[ 7 ] - Evaluation of Anti-nociceptive and Anti-inflammatory Activities of Novel Chalcone Derivatives

Chalcone (1,3-diarylprop-2-en-1-one) derivatives have been introduced as selective cyclooxygenase-2 inhibitors. In the present study, anti-nociceptive and anti-inflammatory effects of eight novel compounds were evaluated in male mice and Wistar rats by using the writhing and formalin-induced paw edema tests respectively. The activities of the compounds were compared with celecoxib as a referenc...

[ 8 ] - Design, Synthesis and Pharmacological Evaluation of Novel 2-[2-(2-Chlorophenoxy) phenyl]-1,3,4-oxadiazole Derivatives as Benzodiazepine Receptor Agonists

New derivatives of 2-[2-(2-Chlorophenoxy)phenyl]-1,3,4-oxadiazole as candidates for agonistic effect on benzodiazepine receptors were synthesized. Conformational analysis and superimposition of energy minima conformers of the novel compounds on estazolam, a known benzodiazepine agonist, revealed that the main proposed benzodiazepine pharmacophores were well matched. In pharmacological eval...

[ 9 ] - An In-Vivo Study on Anticonvulsant, Anxiolytic, and Sedative-Hypnotic Effects of the ‎Polyphenol-Rich Thymus Kotschyanus Extract; Evidence for the Involvement of GABA-A ‎Receptors

Antidepressant-like activity of T. kotschyanus has been recently reported by scientists but insufficient attention has ‎so far been devoted to T. kotschyanus, and there is a lack of information on the other neurobehavioral effects and ‎side effects of this species. In the current study, the anticonvulsant, anxiolytic and sedative-hypnotic, effects of ‎Thymus kotschyanus extract on male NMRI mic...

[ 10 ] - An In-Vivo Study on Anticonvulsant, Anxiolytic, and Sedative-Hypnotic Effects of the ‎Polyphenol-Rich Thymus Kotschyanus Extract; Evidence for the Involvement of GABA-A ‎Receptors

Antidepressant-like activity of T. kotschyanus has been recently reported by scientists but insufficient attention has ‎so far been devoted to T. kotschyanus, and there is a lack of information on the other neurobehavioral effects and ‎side effects of this species. In the current study, the anticonvulsant, anxiolytic and sedative-hypnotic, effects of ‎Thymus kotschyanus extract on male NMRI mic...