BACKGROUND Gabapentin administration into the brain of mice reduces nerve injury-induced hypersensitivity and is blocked by intrathecal atropine and enhanced by intrathecal neostigmine. The authors tested the relevance of these findings to oral therapy by examining the efficacy of oral gabapentin to reduce hypersensitivity after nerve injury in rats and its interaction with the clinically used ...

abstract: warfarin is the most commonly used oral anticoagulant drug in clinical practice with extreme inter and intra-individual variation in pharmacokinetic properties. na valproate, a broad spectrum anticonvulsant agent, is best known for its enzyme inhibition properties and also displacement of protein binding sites. interaction between warfarin and psychotropic drugs including valproate ar...

The present study, on the one hand, attempted to investigate the strategies applied in dispreferred responses by Iranian university students of English and the extent to which pragmatic transfer could occur.  On the other hand, the study aimed to probe into the association between dispreferred organization and turn-shape. To this end, 31 relevant naturally occurring conversations, totaling 120 ...

The complex transporter-cytochrome P450 (CYP) enzyme interplay in the disposition of drugs makes it very challenging to address the safety of clinical drug interactions. Thus, two major subjects are discussed herein. First, the concept of an intravenous drug interaction study (where the perpetrator is administered intravenously or orally while the drug candidate administered intravenously) to f...

objectives: self-assessment, as one type of alternative assessment, with the increased attention to learner-centered curricula, needs analysis, and learner autonomy has gained popularity in recent years. the aim of this study was to investigate the effect of self-assessment on javanroodian foreign language (kordestan) learners’ oral performance ability. methods: the assessment program involved ...

The opportunistic pathogen Candida albicans colonizes the oral cavity and gastrointestinal tract. Adherence to host cells, extracellular matrix and salivary glycoproteins that coat oral surfaces, including prostheses, is an important prerequisite for colonization. In addition, interactions of C. albicans with commensal oral streptococci are suggested to promote retention and persistence of fung...