background and objectives: baculovirus can be used as a vector in gene delivery system. viral envelope of baculovirus would display expressed protein/peptide and it could render as a potential vaccine delivery system. in this regard, the gene coding for a subunit of shiga toxin (stxa) from escherichia coli ( e. coli ) strain was cloned in a baculovirus expression system. stxa subunit has the ab...

protein status of 194 pregnant women and their newborn at a public and a private maternity hospital in tehran was studied. blood samples were taken from all women before delivery and from cords at delivery of the placenta. the following determinations were made: total serum protein, protein fractions, creatinine and urea. in the private group, significantly higher maternal mean values were foun...

objective(s):despite of wide range applications of polymeric nanoparticles in protein delivery, there are some problems for the field of protein entrapment, initial burst and controlled release profile.   materials and methods: in this study, we investigated the influence of some changes in plga nanoparticles formulation to improve the initial and controlled release profile. selected parameters ...

peptide and protein drugs have found an important position in therapeutics. recent advances in pharmaceutical biotechnology have led to an increase in the number of protein products in the market. as these therapeutic proteins and peptides are made available, it will be essential to formulate these drugs into safe and effective delivery systems. the twenty different naturally occurring amino ac...

Oral delivery of proteins such as insulin has been a long-lasting challenge owing to gastrointestinal degradation and poor permeability of therapeutic macromolecules across biological membranes. We have developed mucoadhesive intestinal devices for oral delivery of insulin to address this challenge. Here we demonstrate a combination of intestinal devices and a permeation enhancer, dimethyl palm...

to answer challenge of targeted and controlled drug release in oral delivery various materials were studied by different methods. in the present paper, controlled metal based drug (pd(ii) complex) release manner of β‑lactoglobulin (β-lg) nanoparticles was investigated using mathematical drug release model in order to design and production of a new oral drug delivery system for gastrointestinal ...

Oral administration is the most popular route for systemic effects due to its ease of ingestion, pain, avoidance, versatility and importantly, patient compliance. The development enhanced oral protein delivery technology by mouth dissolving Tablets which may release these drugs in are very promising high molecular weight peptide. Good feel property MDDS helps change basic view medication as “bi...