A growing consensus seems to be emerging that neurocognitive outcomes are poor for patients who have been critically ill with acute respiratory distress syndrome and multiple organ failure. However, intensive care unit delirium, post-traumatic stress disorder, and other outcomes must be considered as potentially confounding factors. Once the uncertainty around the causes of postmorbid cognitive...

ont matter & 2006 006.09.007 thor. Tel.: +44 117 9. : Andrew.McBride@ rtin.gargan@ubht Summary Marfan syndrome is an inherited connective tissue disorder with multi-organ system involvement caused by mutations in the gene encoding the glycoprotein fibrillin-1 (FBN1). The condition presents to the orthopaedic surgeon with an array of musculoskeletal problems. This article will review the pathoge...

Dear Editor, Thrombotic thrombocytopenic purpura (TTP) is a systemic disorder that presents acutely with multiple organ failure. Although defi ned classically as a syndrome with a pentad of features, it is accepted now that a diagnosis can be made with the dyad of microangiopathic haemolytic anaemia and thrombocytopenia. It is recognised that patients with malignancy have a higher risk of getti...

Alagille Syndrome (ALGS) is a rare autosomal dominant disorder that affects multiple organ systems. Cholestasis as a result of a paucity of intrahepatic bile ducts and congenital heart defects are the two most common features of ALGS. We describe a case of ALGS with novel mutations of JAG1 and NOTCH2 genes in a newborn girl with complex congenital heart disease, bilateral dysplastic kidneys, an...

Dialysis disequilibrium syndrome (DDS) is a central nervous system disorder, usually occurs in patients during hemodialysis (HD) or within 24 hours of HD. DDS was first described by Kennedy et al. in 1962. 11 If a critically ill patient on HD develops severe sepsis and septic shock with multiple organ failure (MOF), the adverse effect of HD on the brain is likely to be amplified, which may pred...

mulibrey nanism is a rare autosomal recessive syndrome caused by a mutation in the trim37 gene with severe growth retardation and multiple organ involvement. early diagnosis is important because 50% of the patients develop congestive heart failure owing to constrictive pericarditis, and this condition plays a critical role in the final prognosis. a 37-year-old female patient presented with symp...

Extensive research on the nutritional and medical application of selenium nanoparticles (SeNPs) was performed in past decades. Besides nutritional values, new characteristics such as antibacterial and anticancer properties depict a bright future for high Selenium (Se) consumption in the coming years. Se is essential for the proper functioning of most of the m...

Primary Sjögren's syndrome is a chronic inflammatory disorder with many extraglandular organ systems involved, including the lungs. Diffuse interstitial lung disease is the most serious form of lung involvement. Parenchymal lung involvement in primary Sjögren's syndrome is usually manifested by cough and/or slowly progressive dyspnea and most of the cases present as chronic course. We describe ...

INTRODUCTION Disorders of bladder, bowel and sexual function are common problems in Parkinson’s disease (PD), multiple system atrophy (MSA) and pure autonomic failure (PAF). Although the pathology of PD and MSA is quite different and distinct, the differential diagnosis of the conditions in life, particularly in the early stages, may be difficult and the presence of autonomic failure, as indica...

studies have shown that there are psychiatric patients who tend to aggressively mutilate themselves; they burn or in most cases attempt to burn themselves, attempt to severely damage their genital organs (especially amputate their penis), castrate themselves, axtract their own eyes, amputate their own hands, or commit suicide. this report introduces two psychiatric men, aged 40 and 47, who had ...