نتایج جستجو برای: oxidative stress tissue damage
تعداد نتایج: 1507113 فیلتر نتایج به سال:
Objective(s): To investigate the effect of Ginkgo biloba extract EGb761 in early brain injury (EBI) after subarachnoid hemorrhage (SAH) and its mechanism. Materials and Methods: The SAH rat model was constructed and pre-treated with EGb761.The neurological function, severity of SAH, water content of brain tissue, damage degree of the blo...
Background and purpose: Resveratrol (RSV) is a naturally existing polyphenolic compound abundantly found in grapes and several plants. It has potent free radical scavenger and antioxidative properties with significant effects in reducing oxidative damage. Oxidative stress and mitochondrial dysfunction contribute to PQ induced tissue damage. In this study, the protective effect of RSV was invest...
Redox sensitive transcription factors nuclear factor kappaB (NF-kappaB) and activator protein-1 are involved in the pathogenesis of alcohol-induced disorders. Because of its antioxidative properties, vitamin E may help prevent oxidative stress-induced disorders. The aim of the present study was to delineate the molecular mechanisms associated with alcohol-induced oxidative stress and to see whe...
Periodontitis is a common inflammatory disease. It characterized by destruction of the supporting structures teeth and could lead to tooth loss systemic inflammation. Bacteria in inflamed gingival tissue virulence factors are capable entering bloodstream induce response, thus influencing pathological process many diseases, such as cardiovascular diabetes, chronic kidney disease, well liver inju...
Introduction: Oxidative stress causes DNA damage and apoptosis and leads to cardiovascular disease. The aim of this study was to evaluate the effect of a course of aerobic exercise with hypoallergenic supplement of Tribulus terrestris on mitochondrial oxidative stress markers of cardiac tissue in rats toxicated with hydrogen peroxide. Method: To implementation of this experimental research, 4...
Mitochondrial dysfunction is the most prominent source of oxidative stress in acute and chronic kidney disease. NLRX1 is a receptor of the innate immune system that is ubiquitously expressed and localized in mitochondria. We investigated whether NLRX1 may act at the interface of metabolism and innate immunity in a model of oxidative stress. Using a chimeric mouse model for renal ischemia-reperf...
conclusions the di was found to induce liver damage by oxidative stress mechanisms. silibinin reduced the oxidative stress by inducing antioxidant mechanisms, thereby showing protective effect against di induced liver damage. further studies with silibinin should be performed regarding di toxicity. materials and methods thirty two wistar albino rats were divided into four groups, as follows: 1)...
Oxidative stress in brain is emerging as a potential causal factor in aging and age-related neurodegenerative disorders. Brain tissue from living patients is difficult to acquire; hence, animal models of aging and age-related neurodegenerative disorders, though not perfect models, have provided tissue to study the role of oxidative stress in these disorders. In this review, the central role of ...
Persistent inflammation and the generation of reactive oxygen and nitrogen species play pivotal roles in tissue injury during disease pathogenesis and as a reaction to toxicant exposures. The associated oxidative and nitrative stress promote diverse pathologic reactions including neurodegenerative disorders, atherosclerosis, chronic inflammation, cancer, and premature labor and stillbirth. Thes...
Hypothermia may attenuate the progression of ischemia-induced damage in liver. Here, we determined the effects of a brief cycle of hypothermic preconditioning applied before an ischemic/reperfusion (I/R) episode in isolated perfused rat liver (IPRL) on tissue damage and oxidative stress. Rats (male, 200-250 g) were anaesthetised with sodium pentobarbital (60 mg·kg-1 i.p) and underwent laparatom...
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