An 11 year – old mixed female Labrador was presented with two masses in trunk and neck. The tumoral masses were excised and sent for histopathological and immunohistochemical analyses. Histopathological examination of masses revealed diffuse infiltration of small sized lymphoid cells in subcutaneous tissue which were intense around the blood vessels. More than 10% lymphoid cells were CD3 positi...

BACKGROUND Arsenic is both a human carcinogen and a chemotherapeutic agent, but the mechanism of neither arsenic-induced carcinogenesis nor tumor selective cytotoxicity is clear. Using a model cell line in which p53 expression is regulated exogenously in a tetracycline-off system (TR9-7 cells) , our laboratory has shown that arsenite disrupts mitosis and that p53-deficient cells [p53(-)], in co...

Selectively targeting the cancer cells by reactivating cell killing function of p53 protein - IJPCA- Print ISSN No: 2394-2789 Online No:- 2394-2797 Article DOI 10.18231/j.ijpca.2022.010, International Journal Pharmaceutical Chemistry and Analysis-Int J Pharm Chem Anal

Abstract Background Colorectal cancer is considered a potential causative agent of morbidity and death, making it particularly dangerous malignancy. The current study aims to assess the efficacy ferulic acid (FA) attenuate harmful side effect 5-fluorouracil (5FU) in colon tissues induced by 1,2-dimethylhydrazine (DMH). Results Regarding male Wistar-albino rats ( Rattus norvegicus ), combined FA...

Abstract INTRODUCTION Mouse models are instrumental in advancing our understanding of glioblastoma (GBM), however many commonly used have features that limit their practicality or applicability. These limitations can include an incomplete immune context, a requirement for complex breeding strategies, high cost specialized lines, and unpredictability where tumors arise. We sought to develop vali...

Abortive infection of BALB/c mouse embryo fibroblasts differing in p53 gene status (p53(+/+) versus p53(-/)(-)) with simian virus 40 (SV40) revealed a quantitatively and qualitatively decreased transformation efficiency in p53(-/-) cells compared to p53(+/+) cells, suggesting a supportive effect of wild-type (wt) p53 in the SV40 transformation process. SV40 transformation efficiency also was lo...

Tumor suppressor p53 plays an essential role in protecting cells from malignant transformation by inducing cell-cycle arrest and apoptosis. Mutant p53 that is detected in more than 50% of cases of cancers loses its role in suppression of tumors but gains in oncogenic function. Strategies to convert mutant p53 into wild-type p53 have been suggested for cancer prevention and treatment, but they f...

Abstract Background Bisphenol A (BPA) causes environmental pollution and is used as a natural antioxidant to protect against chemical side-effects. Costus well-known medicinal plant containing several biologically active compounds. We investigated the protective effects of costus extract toxic BPA in rat testes. Results Biochemical immunohistochemical investigations revealed that bisphenol redu...