BACKGROUND Tolerance to the analgesic effect of morphine complicates the management of chronic pain states. The authors studied the ability of the glycine/N-methyl-D-aspartate receptor antagonist (+)-HA966 to modify morphine tolerance in a rat model of neuropathic pain. METHODS Mononeuropathy was induced by placing four ligatures around the common sciatic nerve. The 4-day pretreatment regimen...

BACKGROUND Recent results in birds, marsupials, rodents and nonhuman primates suggest that phylogeny and ecological factors such as body size, diet and postural habit of a species influence limb usage and the direction and strength of limb laterality. To examine to which extent these findings can be generalised to small-bodied rooting quadrupedal mammals, we studied trees shrews (Tupaia belange...

These notes contain a discussion of a minor update of the GBRV potentials as well as new testing data on both the GBRV potentials and the recently released JTH PAW set. This testing includes a new zinc blende test set, which has been examined with the ∆-factor test[1]. The updated testing data are consistent with earlier tests which show very good performance for the GBRV potential set. The tes...

The interrelationship of hydrostatic pressure and osmotic forces across the capillary membrane are described by the Starling equation [lo]. Increasing pulmonary capillary hydrostatic pressure is a cause of pulmonary edema 131. Pulmonary edema develops at a lower hydrostatic pressure when plasma colloid oncotic pressure is lowered suggesting that the gradient between colloid oncotic pressure (CO...

We sought to quantify the autocorrelation properties and fractal dynamics of interbreath interval (IBI) variability to see if short-term airway pressure (Paw) increases affected scaling behaviour. Data were collected in anaesthetised children at basal (Ba), medium (Me) and high (Hi) Paw. Consistent with short-range dependence, the autocorrelation function was significant at five (Ba) to three (...

Administration of ethanol (95%) extract (45 mg/kg body wt/day for 28 days) of garlic (A. sativum) to alloxan induced diabetic (ALX-D) mice significantly lowered the serum glucose levels, nociceptive response in tail-flick, hotplate, allodynia, formalin test and relative thickness, weight of hind paw in formalin induced Paw oedema test, over 28 days, thus, showing the reversal trend in hyperglyc...

Twenty-five newborn infants with severe respiratory failure responding poorly to conventional mechanical ventilation were switched to high-frequency positive-pressure ventilation (HFPPV) at 90 to 180 cycle/min (mean 158), an estimated tidal volume less than or equal to 3 ml/kg body weight, an inspiratory time of 0.1 sec, and a PEEP of 3 to 17 cm H2O. In all infants, HFPPV increased PaO2 (mean 6...

OBJECTIVE To evaluate whether the shape of the airway pressure-time (Paw-t) curve during constant flow inflation corresponds to radiologic evidence of tidal recruitment or tidal hyperinflation in an experimental model of acute lung injury. DESIGN Prospective randomized laboratory animal investigation. SETTING Department of Clinical Physiology, University of Uppsala, Sweden. SUBJECTS Anest...

Accurate mechanics measurements during high-frequency oscillatory ventilation (HFOV) facilitate optimizing ventilator support settings. Yet, these are influenced substantially by endotracheal tube (ETT) contributions, which may dominate when leaks around uncuffed ETT are present. We hypothesized that 1) the effective removal of ETT leaks may be confirmed via direct comparison of measured vs. mo...