BACKGROUND Endothelin-1 participates in the pathophysiology of heart failure. The reasons for the lack of beneficial effect of endothelin antagonists in heart failure patients remain however speculative. The anti-apoptotic properties of ET-1 on cardiomyocytes could be a reasonable explanation. We therefore hypothesized that blocking the pro-apoptotic TNF-α pathway using pentoxifylline could pre...

Behavioral perturbations associated with nandrolone decanoate abuse by athletes and adolescents may be attributed to oxidative stress and inflammation. However, the underlying mechanisms are not yet fully explored. On the other hand, the natural antioxidant lipoic acid can pass the blood brain barrier and enhance Nrf2/HO-1 (nuclear factor erythroid-2 related factor 2/heme oxygenase-1) pathway. ...

Introduction: Precision-cut liver slices are a promising alternative to cell culture models for the study of hepatic stellate cell (HSC) activation and fibrogenesis since HSC are maintained in their original extracellular matrix and multicellular milieu. In the present study we evaluated human liver slices as a tool to study fibrogenesis and to test antifibrotic drugs. Methods: Firstly we deter...

background: it was hypothesized that the use of pentoxifylline would increase arterial o2 saturation and increase exercise tolerance in patients with chronic obstructive pulmonary disease (copd). methods: we tested this hypothesis in 23 patients with copd and pulmonary hypertension. patients were randomized to receive pentoxifylline or placebo, each for a 12-week period, in a prospective, doubl...

The effect of pentoxifylline (Trental) on the phagocytic capacity, cAMP levels, and superoxide anion production of human peripheral blood monocytes and polymorphonuclears (PMNs) was studied. The drug inhibited the phagocytosis of latex particles by both monocytes and PMNs in a dose-dependent manner. In addition, superoxide anion production during the phagocytic process was also reduced followin...

Background and Aim: Despite the advances in maxillofacial surgery, impaired bone healing remains a concern for surgical teams. Effects of sildenafil and pentoxifylline on healing of bone fractures have not been well investigated. This study aimed to assess the effects of sildenafil and pentoxifylline phosphodiesterase inhibitors on healing of mandibular fractures in rats. Materials and Methods...

In a prospective, randomized, parallel study, two regimens of platelet-suppressant therapy (PST)--dipyridamole-aspirin and pentoxifylline-aspirin--were compared with standard oral anticoagulation with warfarin in the prevention of prosthetic heart valve thromboembolism. In the entire group of 254 patients followed for 395.6 patient-years, the thromboembolic rate was significantly less in the wa...

Pentoxifylline increases erythrocyte flexibility, reduces blood viscosity,and inhibits platelet aggregation and is thus used in the treatment of peripheral vasculardisease. It is transformed into at least seven phase I metabolites, of which two, M1 andM5, are active. The reduction of the keto group of pentoxifylline to a secondary alcoholin M1 takes place chiefly in erythrocytes...

Twenty patients with Schamberg's disease were started on pentoxifylline (400 mg once daily) for a period of 8 weeks. Improvement was assessed at 2 weekly intervals by two observers independently and graded as mild (< 25%, moderate (25-50%) and marked (>50%). Marked improvement was observed in 10/20(50%) patients. We conclude that pentoxifylline should be considered as first line therapy in all ...