نتایج جستجو برای: pfmdr1
تعداد نتایج: 279 فیلتر نتایج به سال:
Treatment of the symptomatic asexual stage of Plasmodium falciparum relies almost exclusively on artemisinin (ART) combination therapies (ACTs) in endemic regions. ACTs combine ART or its derivative with a long-acting partner drug to maximize efficacy during the typical three-day regimen. Both laboratory and clinical studies have previously demonstrated that the common drug resistance determina...
Malaria is a major public health problem in tropical and subtropical countries, including India. This study elucidates the cause of chloroquine treatment failure (for Plasmodium falciparum infection) before the introduction of artemisinin combination therapy. One hundred twenty-six patients were randomized to chloroquine treatment, and the therapeutic efficacy was monitored from days 1 to 28. A...
Abstract Background The national policy for malaria treatment of the Democratic Republic Congo recommends two first-line artemisinin-based combinations uncomplicated malaria: artesunate-amodiaquine and artemether-lumefantrine. This study investigated presence markers associated with resistance to current combination therapy (ACT) in isolates Plasmodium falciparum from failure patients Congo. Me...
Abstract Background Cape Verde is an archipelago located off the West African coast and in a pre-elimination phase of malaria control. Since 2010, fewer than 20 Plasmodium falciparum cases have been reported annually, except 2017, when outbreak Praia before rainy season led to 423 autochthonous cases. It important understand genetic diversity circulating P. inform on drug resistance, potential ...
We conducted a 28-day follow-up of 17 Laotian patients diagnosed with uncomplicated Plasmodium falciparum malaria treated with mefloquine (Mephaquine, MQ) alone to determine the efficacy. All patients were completely cured with MQ, without reappearance of asexual stage parasitemia at follow-up. Of the 7 isolates tested for genotypic analysis, one isolate was a Y86 mutant type of the pfmdr1 gene...
We cultured Plasmodium falciparum parasites from 98 Ugandan children with malaria and determined the complexity of infection (COI) on the basis of msp-2 polymorphisms daily for 9 days. The mean COI decreased during culture from 1.73 to 1.56. New strains appeared after day 0 in 20 cultures. Strains disappeared after day 0 in 56% of 45 cultures that were initially mixed; persisting strains more c...
Background: Antimalarial drug resistance is a major obstacle to sustainable malaria control. Here we use amplicon sequencing describe molecular markers of in Plasmodium falciparum parasites from Kilifi county the coastal region Kenya over 25-year period. Methods: We performed P. on 1162 malaria-...
We assessed Plasmodium falciparum drug resistance markers in parasites collected in 2012, 2013, and 2015 at 3 sites in Uganda. The prevalence and frequency of parasites with mutations in putative transporters previously associated with resistance to aminoquinolines, but increased sensitivity to lumefantrine (pfcrt 76T; pfmdr1 86Y and 1246Y), decreased markedly at all sites. Antifolate resistanc...
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