نتایج جستجو برای: pfmdr1

تعداد نتایج: 279  

2011
Pedro Eduardo Ferreira Gabrielle Holmgren Maria Isabel Veiga Per Uhlén Akira Kaneko José Pedro Gil

ATP-Binding Cassette (ABC) transporters are efflux pumps frequently associated with multidrug resistance in many biological systems, including malaria. Antimalarial drug-resistance involves an ABC transporter, PfMDR1, a homologue of P-glycoprotein in humans. Twenty years of research have shown that several single nucleotide polymorphisms in pfmdr1 modulate in vivo and/or in vitro drug susceptib...

Journal: :Antimicrobial agents and chemotherapy 2010
Nanhua Chen Marina Chavchich Jennifer M Peters Dennis E Kyle Michelle L Gatton Qin Cheng

Amplification of the Plasmodium falciparum multidrug resistance 1 gene (pfmdr1) has been implicated in multidrug resistance, including in vitro resistance to artelinic acid (AL). The stability and fitness of having multiple copies of pfmdr1 are important factors due to their potential effects on the resistance phenotype of parasites. These factors were investigated by using an AL-resistant line...

Journal: :Antimicrobial agents and chemotherapy 2008
Rajeev K Mehlotra Gabriel Mattera Moses J Bockarie Jason D Maguire J Kevin Baird Yagya D Sharma Michael Alifrangis Grant Dorsey Philip J Rosenthal David J Fryauff James W Kazura Mark Stoneking Peter A Zimmerman

Mutations in the chloroquine resistance (CQR) transporter gene of Plasmodium falciparum (Pfcrt; chromosome 7) play a key role in CQR, while mutations in the multidrug resistance gene (Pfmdr1; chromosome 5) play a significant role in the parasite's resistance to a variety of antimalarials and also modulate CQR. To compare patterns of genetic variation at Pfcrt and Pfmdr1 loci, we investigated 46...

Journal: :Antimicrobial agents and chemotherapy 2014
Nathalie Wurtz Bécaye Fall Aurélie Pascual Mansour Fall Eric Baret Cheikhou Camara Aminata Nakoulima Bakary Diatta Khadidiatou Ba Fall Pape Saliou Mbaye Yaya Diémé Raymond Bercion Boubacar Wade Bruno Pradines

The involvement of Pfmdr1 (Plasmodium falciparum multidrug resistance 1) polymorphisms in antimalarial drug resistance is still debated. Here, we evaluate the association between polymorphisms in Pfmdr1 (N86Y, Y184F, S1034C, N1042D, and D1246Y) and Pfcrt (K76T) and in vitro responses to chloroquine (CQ), mefloquine (MQ), lumefantrine (LMF), quinine (QN), monodesethylamodiaquine (MDAQ), and dihy...

Journal: :Antimicrobial agents and chemotherapy 2014
Jelagat Cheruiyot Luicer A Ingasia Angela A Omondi Dennis W Juma Benjamin H Opot Joseph M Ndegwa Joan Mativo Agnes C Cheruiyot Redemptah Yeda Charles Okudo Peninah Muiruri Ngalah S Bidii Lorna J Chebon Paul O Angienda Fredrick L Eyase Jacob D Johnson Wallace D Bulimo Ben Andagalu Hoseah M Akala Edwin Kamau

In combination with antibiotics, quinine is recommended as the second-line treatment for uncomplicated malaria, an alternative first-line treatment for severe malaria, and for treatment of malaria in the first trimester of pregnancy. Quinine has been shown to have frequent clinical failures, and yet the mechanisms of action and resistance have not been fully elucidated. However, resistance is l...

Journal: :Antimicrobial agents and chemotherapy 2006
Christian Dokomajilar Samuel L Nsobya Bryan Greenhouse Philip J Rosenthal Grant Dorsey

Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1 alleles 86N, 184F, and 1246D significantly increased in prevalence after treatment. All samples had a single pfmdr1 copy. Treatment with artemether-lumefantrine selects for polymorphisms that may alter anti...

Journal: :The Journal of infectious diseases 2005
Anne-Catrin Uhlemann Michael Ramharter Bertrand Lell Peter G Kremsner Sanjeev Krishna

The study of molecular markers of drug resistance is particularly important in surveillance studies of drugs, such as mefloquine, that still retain efficacy in sub-Saharan Africa yet have encountered resistance elsewhere. In a recent study in Thailand, we identified amplification of the Plasmodium falciparum multidrug resistance gene 1 (pfmdr1) as being the most important predictor of in vitro ...

2018
Vito Baraka Hypolite Muhindo Mavoko Carolyn Nabasumba Filbert Francis Pascal Lutumba Michael Alifrangis Jean-Pierre Van Geertruyden

BACKGROUND The emergence of resistance against artemisinin combination treatment is a major concern for malaria control. ACTs are recommended as the rescue treatment, however, there is limited evidence as to whether treatment and re-treatment with ACTs select for drug-resistant P. falciparum parasites. Thus, the purpose of the present study is to investigate the impact of (re-)treatment using a...

Journal: :The Journal of infectious diseases 2014
Melissa D Conrad Norbert LeClair Emmanuel Arinaitwe Humphrey Wanzira Abel Kakuru Victor Bigira Mary Muhindo Moses R Kamya Jordan W Tappero Bryan Greenhouse Grant Dorsey Philip J Rosenthal

BACKGROUND Artemisinin-based combination therapies, including artemether-lumefantrine (AL) and dihydroartemisinin-piperaquine (DP), are recommended to treat uncomplicated falciparum malaria. Sensitivities to components of AL and DP are impacted by polymorphisms in pfmdr1 and pfcrt. We monitored changes in prevalences of polymorphisms in Tororo, Uganda, from 2008 to 2012. METHODS Polymorphic l...

Journal: :The Southeast Asian journal of tropical medicine and public health 2005
Toshimitsu Hatabu Shin-ichiro Kawazu Somei Kojima Kumiko Sato Pratap Singhasivanon Sornchai Looareesuwan Shigeyuki Kano

In vitro drug susceptibility to chloroquine (CQ) and mefloquine (MF) were assessed in 39 P. falciparum isolates from the Thai-Myanmar border area. To further characterize CQ- and MF-resistance profiles in this area, we also analyzed pfcrt K76T mutation that is critical for CQ resistance, and pfmdr1 polymorphism that has an association with MF resistance. Eighteen isolates were successfully exam...

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