An accurate and economical spectrophotometric method for the determination of Darunavir in pure and dosage forms has been described in the present work. Stocksolution of Darunavir was prepared by initially by dissolving 100 mg of Darunavir in 10 mL of methanol and made up to 100 mL with distilled water. The values obtained by the proposed and reference method for formulations were compared stat...

Two simple, specific, accurate, precise, sensitive and cost effectivespectrophotometric methods have been developed and validated for quantification oflinagliptin in pure form and pharmaceutical formulations. Method A is established onthe computation of absorbance of purple coloured chromogen complex at 463 nmwhich is formed by the condensation reaction of the primary amine group oflinagliptin ...

A description of the development of a strategy for improving the standardization of coagulation tests and the rationale behind the recommendations that follow are the subject of this position paper. Such an endeavor has been occasioned by the advances in the technology for the diagnosis and therapeutic treatment of hemorrhagic and thromboembolic diseases. These and anticipated further advances ...

In pharmaceutical companies and research institutes, many toxicity tests are performed with laboratory animals. This study was performed to produce reference data for eye toxicity tests and to investigate the ophthalmic diseases of 408 ICR mice and 119 BALB/c mice, which are commonly used as subjects in toxicity tests. The experimental animals without clinical disorders were selected regardless...

BACKGROUND Several factors, which are components of pharmaceutical care, can influence a patient's choice of a community pharmacy store and contribute to frequent visits to the same pharmacy. OBJECTIVES To compare factors that influence a patient's choice of pharmacy in Poland and in the UK, to identify which of them are components of pharmaceutical care, and to relate them to patient loyalty...

Occupational exposures to glucocorticoids are still a neglected issue in some work environments, including pharmaceutical plants. We developed an analytical method to quantify simultaneously 21 glucocorticoids using UPLC coupled with mass spectrometry to provide a basis to carry out environmental monitoring. Samples were taken from air, hand-washing tests, pad-tests and wipe-tests. This paper r...

according to the vital role of pharmaceutical industry in health care system, pharmaceutical supply chain security, standard production and distribution of the pharmaceutical products are of great importance for pharmaceutical companies. therefore, applying technology, especially radio frequency identification (rfid), is essential to achieve these goals. moreover, due to the importance of secur...

agility is the fundamental characteristic of a supply chain needed for survival in turbulent markets, where environmental forces create additional uncertainty resulting in higher risk in the supply chain management. in addition, agility helps providing the right product, at the right time to the consumer. the main goal of this research is therefore to promote supplier selection in pharmaceutica...

Widespread use of pharmaceuticals has resulted in mixture concentrations ranging from mg/L in effluent to µg/L concentrations in surface water. In a 2008 study, 13 pharmaceuticals, ranging in amounts from 0.0028 to 0.1757 µg/l, were identified in the Tennessee River, USA and its tributaries. In order to address the need for risk assessment of environmentally relevant pharmaceutical mixtures, <e...