The effects of cortisone on the dietary induction and repression of serine dehydrase, ornithine transaminase, and tyrosine transaminase were studied. In rats pretreated with cortisone dietary induction was affected relatively little, but carbohydrate repression was largely eliminated. The effects of cortisone and phenobarbital on the dietary induction of serine dehydrase and ornithine transamin...

The effects of cortisone on the dietary induction and repression of serine dehydrase, ornithine transaminase, and tyrosine transaminase were studied. In rats pretreated with cortisone dietary induction was affected relatively little, but carbohydrate repression was largely eliminated. The effects of cortisone and phenobarbital on the dietary induction of serine dehydrase and ornithine transamin...

The "EMIT" enzyme immunoassay system (Syva) that involves use of glucose-6-phosphate dehydrogenase (EC 1.1.1.49) as the enzyme label has been adapted to a fully mechanized kinetic enzyme analyzer for analysis of phenobarbital, phenytoin, and primidone. This procedure, compared with the gas-chromatographic procedure of Kupferberg [Clin. Chim. Acta 29, 283 (1970)], gave a weighted regression line...

phenobarbital is a phenobarbiturate used as a sedative, anticonvulsant, or hypnotic with the doses prescribed and can cause teratogenic effects. the goal of this study was to examine an alternative method for the recognition of the mechanism or the bimolecular potential changes in mice fetus caused by phenobarbital using ftir micro spectroscopy. the mice were injected with phenobarbital (120mg/...

We describe, the first case of phenobarbital-induced DRESS syndrome presenting as a lichenoïd eruption. A 49-year-old man had received phenobarbital for a cerebral metastasis. Twenty-five days later, he developed a purplish skin eruption, odynophagia, oral mucosal erosion and fever. Physical examination revealed a cervical lymphadenopathy and facial edema associated to a diffuse violaceous macu...

Potassium bromide, phenobarbital, or a combination of both is commonly used in the treatment of canine epilepsy. Several cases of clinical pancreatitis have been reported in dogs after treatment with potassium bromide, but the risk of elevated serum canine pancreatic lipase immunoreactivity concentrations in dogs treated with potassium bromide and/or phenobarbital has not previously been evalua...

A simple, rapid, quantitative, low-cost UV-differential spectrophotometric method for the routine monitoring of phenobarbital in serum and cerebrospinal fluid is described. This method can also be used for monitoring methylphenobarbital (Phemiton) and primidone (Mysoline), since the major active metabolite of both drugs is phenobarbital. The basis for our procedure is Goldbaum's method (Anal. C...

The antiepileptic drugs diphenylhydantoin and phenobarbital were measured in serum by a new commercially available enzyme immunoassay procedure ("EMIT," Syva Corp.). The procedure requires less than 5 min and no more than 50 mul of serum per determination. It is simple; only four steps (pipetting and diluting with an automatic pipettor-dilutor) are required before spectrophotometry. Twenty repl...