Introduction: Gait retraining is a novel management strategy which has shown ability to reduce pain and the peak knee adduction moment (KAM) (a surrogate measure of medial load) in people with osteoarthritis. However, no published study compared gait placebo change does not affect KAM). Therefore, it unknown whether improvement due KAM reduction. Our primary aim was determine joint loading outc...

objective: major depression is a mood disorder that causes changes in physical activity, appetite, sleep and weight. regarding the role of zinc in the pathology of depression, the present study was aimed to investigate the effects of zinc supplementation in the treatment of this disease. methods: this study was a double-blind randomized clinical trial. forty four patients with major depression ...

background doctor-patient communication has far reaching influences on the overall well-being of the patients. words are powerful tools in the doctor’s armamentarium, having both healing as well as harming effects. doctors need to be conscious about the choice of their words. this study aimed to determine the frequency and pattern of nocebo phenomenon (np) un-intentionally induced by the commun...

By using deceptive experiments in which participants are informed that they received caffeine when, fact, an inert substance (i.e., placebo), several investigations have demonstrated exercise performance can be enhanced to a similar degree as known dose. This ‘placebo effect’ phenomenon may part of the mechanisms explaining caffeine’s ergogenicity exercise. However, there is no study has establ...

This subgroup analysis of the Effisayil 1 trial (NCT03782792) compared patient characteristics and assessed effects spesolimab in patients with a GPP flare with/without baseline systemic inflammation. Patients were randomised 2:1 to single infusion IV 900 mg or placebo. Systemic inflammation at was defined as elevated CRP (>ULN 10 mg/L) neutrophil count (>ULN, 7.23x109/L). GPPGA pustulation sub...

DUPISTAD (NCT04033367) evaluated the impact of dupilumab on sleep. Adults with moderate-to-severe AD (EASI ≥12, Pruritus numerical rating scale (NRS) ≥ 3 and sleep NRS ≥5) were randomized 2:1 to 300mg every 2 weeks (q2w) or placebo for 12 (W12); both groups permitted concomitant topical corticosteroids. The primary efficacy endpoint was quality percentage change from baseline W12, assessed by 1...

Immune dysregulation may be involved in the pathophysiology of schizophrenia. Given need for new treatment options schizophrenia, anti-inflammatory medication could a potential this illness. In double-blind, placebo-controlled clinical trial, patients with schizoaffective disorder or psychosis NOS were randomized 1:1 to either prednisolone placebo, addition their regular antipsychotic medicatio...