The safety and efficacy of intralesionally administered interferon alfa-2b were assessed in 11 patients suffering from condylomata acuminata for four to 10 months for whom application of podophyllum resin had proved unsuccessful. Three warts from each patient were injected with 10(6) IU interferon alfa-2b three times a week for three weeks. Treatment was followed by a 13 week observation period...

HPLC, column and thin layer chromatography guided studies led to the isolation of seven different compounds in methanolic extracts of Podophyllum hexandrum. The isolated compounds were analyzed using LC-MS and High Performance Liquid Chromatography (HPLC) studies interfaced to mass spectroscopy. Isolated compounds were used successfully as chemical markers for the comparison of the twelve diffe...

The epoxy resin epon 812 has been used in this department to embed a variety of normal and pathological tissues for a number of years. Unfortunately during the past 18 months sectioning qualities of polymerized epon blocks have become variable in an unpredictable manner. It is possible that the batch variation in the quality and composition of the dodecynl succinic anhydride (DDSA) could be res...

PURPOSE The safety and efficacy of the combined use of sorafenib and yttrium-90 resin microspheres (Y90 RMS) to treat advanced hepatocellular carcinoma (HCC) is not well established. We determined the incidence of adverse events with this combination therapy in patients with advanced HCC at our institution and analyzed the treatment and survival outcomes. MATERIALS AND METHODS We reviewed the...

I. The Intravenous, Subcutaneous and Cutaneous Toxicity of bis(8-Chloroethyl) Sulfide (Mustard Gas) and of Various Derivatives. William P. Anslow, Jr., David A. Karnofsky, B. Val Jager and Homer W. Smith 1 II. The Effects of Intravenous Injection of Tetra-Ethyl-Ammonium Chloride On the Intra-Arterial Blood Pressure and Other Physiologic Variables in Man. George E. Brown, Jr., Earl H. Wood and E...

CMAJ • SEPTEMBER 15, 2009 • 181(6-7) © 2009 Canadian Medical Association or its licensors 397 A23-year-old man was referred to us with a 4-year history of flesh-coloured, spiny papules around the coronal rim of his glans penis (Figure 1). The papules were 1–2 mm in diameter. The patient felt stigmatized by their appearance. A diagnosis of pearly penile papules (also known as PPP) was made. Pear...

A 31-year-old white man with developmental delay and a history of epilepsy was seen in February 2008 with multiple warts on his hands that had been present for several years. He had previously been treated with podophyllin, 2 different concentrations of salicylic acid (25% and 40%), and oral cimetidine, and his regular medications included lamotrigine, valproate, topiramate, and levetiracetam. ...

Podophyllum hexandrum a perennial herb, bearing the common name Himalayan Mayapple known as Aindri (a divine drug) in ancient times is native to the lower elevations in and surrounding the Himalaya. It has been reported to be used through the ages and in modern times as an intestinal purgative and emetic, salve for infected and necrotic wounds, and inhibitor of tumor growth. The rhizome of the ...

Background: Condyloma acuminata is a common sexually transmitted disease of sexually active adults caused by HPV having variable response to the different available therapies and none of them have proved to be uniformly effective as recurrences are common. Objective: A randomized, single blinded, paralleled group, intention to treat prospective study was conducted not only to compare the two tr...