A 21 year old male ingested podophyllin in a suicide attempt. The disorder was marked by seizures, coma, peripheral neuropathy, renal failure and acute necrotizing myopathy, an unusual finding. The coma and systemic disturbances resolved within three weeks. The myopathy resolved in 7 weeks, demonstrating a high capacity of muscle recuperation. The sensorimotor peripheral neuropathy persisted un...

INTRODUCTION Topical application of podophyllin is a routine procedure in patients with ano-genital warts. Podophyllin is a crude plant extract and is therefore not a well-defined product. It may contain variable amounts of the active lignan podophyllotoxin and the majority of the dry weight of podophyllin is made up of substances never identified. OBJECTIVE The purpose of the study was to es...

Seventy-three patients with anogenital warts were randomly allocated to a double-blind comparison of treatment with trichloracetic acid (50%) and podophyllin (25%) versus podophyllin (25%) alone. There was no significant difference in the resolution of warts in the two treatment groups among patients followed for three months. Of patients free of warts at six weeks, treatment with trichloraceti...

OBJECTIVE To compare the effectiveness and cost of self treatment of penile warts with a commercial preparation of podophyllotoxin 0.5% (PDX 0.5%) with podophyllin 0.5% and podophyllin 2.0% sourced from Podophyllum emodii. DESIGN A prospective double blind randomised study. SUBJECTS 315 patients with penile warts attending two departments of genitourinary medicine. MAIN OUTCOME MEASURES A...

Objectives: To compare between pulsed dye laser and podophyllin resin in treatment of genital warts regarding pain, number of sessions, clearance rate, and recurrence. Methods: Thirty-nine female patients were divided into two groups, the first group; 20 patients was treated with podophyllin resin, the second group 19 patients was treated with pulsed dye laser (Candela) 595nm, 1.5 ms pulse dura...

SUMMARY Effects on mitosis in mouse vaginal and rectal epithelium were used to screen antimitotic properties of drugs given i.p. Test drugs were given i.p. at time zero, podophyllin was injected at 2 hr, and the animals were killed at 8 hr. Both vagina and rectum were removed en bloc. Mitotic cells in the epithelia were counted histologically. The validity of the system was ascertained by testi...

It has been well shown through the observations both in vivo (King and Sullivan 1947, Belkin 1948, Greenspan, Leiter and Shear 1950, Leiter, Downing, Hartwell and Shear 1950, MacCardle 1951, Makino and Tanaka 1953, etc.) and in vitro (Ormsbee, Cornman and Berger 1949, Makino and Cornman 1953) that podophyllin and its components do exert a powerful mitotic poisoning effect and do damage both mal...

572 patients with solitary or multiple genital warts attending the Department of Genitourinary Medicine at the Royal Victoria Hospital, Bournemouth, U.K. between January 1981 and December 1981 were allocated to either podophyllin or cryotherapy for the treatment of their warts. Of 350 patients successfully treated for their warts and returned for a follow-up examination 6 weeks or more after co...

Four hundred and fifty patients were enrolled into a randomised clinical trial in a public sexually transmitted diseases clinic to evaluate the efficacy of podophyllin, cryotherapy, and electrodesiccation for treatment of external genital warts. Complete clearance of warts was observed in 41%, 79%, and 94% of patients who received up to six weekly treatments of podophyllin, cryotherapy, and ele...

The increasing incidence of genital warts has led to more public awareness of this infection and its possible sequelae. Currently available treatment remains unsatisfactory, and there is pressure to develop effective and convenient alternatives. Podophyllotoxin is standardised and stable, whereas podophyllin has a variable composition. In an open comparison of self applied podophyllotoxin 0.5% ...