the formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a hydroph...

This article reviews work completed by the authors to examine how musculotendon forces from index finger muscles impact finger kinetics and kinematics. Results were obtained from in vivo studies, computer simulations, and cadaver investigations. Passive joint impedance and finger posture had particularly strong effects on force transmission in the fingers.

Background Poor and fragmentary data was available regarding the effects of recombinant-LH (r-LH) in in-vitro granulosa and theca cells of human origin. No data was available from in vivo studies regarding the effects of r-LH supplementation on SCF,EGF,ERK-1/2 and AKT-1 pathways in the follicular fluid of older-poor-responder women undergoing IVF cycle. Evidence from in-vitro and animal studies...

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We present an algorithm for computing Minkowski sums among surfaces of revolution and surfaces of linear extrusion, generated by slope-monotone closed curves. The special structure of these simple surfaces allows the process of normal matching between two surfaces to be expressed as an explicit equation. Based on this insight, we also present an efficient algorithm for computing the distance be...

We show that for polytopes P1, P2, . . . , Pr ⊂ R, each having ni ≥ d + 1 vertices, the Minkowski sum P1 + P2 + · · · + Pr cannot achieve the maximum of ∏ i ni vertices if r ≥ d. This complements a recent result of Fukuda & Weibel (2006), who show that this is possible for up to d − 1 summands. The result is obtained by combining methods from discrete geometry (Gale transforms) and topological ...

It is known that in the Minkowski sum of r polytopes in dimension d, with r < d, the number of vertices of the sum can potentially be as high as the product of the number of vertices in each summand [2]. However, the number of vertices for sums of more polytopes was unknown so far. In this paper, we study sums of polytopes in general orientations, and show a linear relation between the number o...