Background: Diagnostic ultrasound has been used to detect human disease especially fetus abnormalities in recent decades. Although the harmful effects of diagnostic ultrasound on human have not been established so far, several researchers showed it has had bioeffects in cell lines and in experimental animals. Three-dimensional (3D), four-dimensional (4D), and color Doppler sonography are new te...

Background: Radiation therapy is among the most conventional cancer therapeutic modalities with effective local tumor control. However, due to the development of radio-resistance, tumor recurrence and metastasis often occur following radiation therapy. In recent years, combination of radiotherapy and gene therapy has been suggested to overcome this problem. The aim of the current study was to e...

background and purpose: gastric cancer (gc) is one of the most common cancers worldwide and in iran. as conventional therapies such as surgery and chemotherapy are invasive with adverse effects, current studies are important as they are conducted to find natural compounds with few adverse effects. in this study, melittin with 26 amino acids was isolated and purified from bee venom and its effec...

Objective: Anticancer activities of Schiff bases S1 and S2 against MG-63 human osteosarcoma cells were performed described using an in vitro evaluation employing cytotoxicity apoptosis assay. Methods: used MTT assay to examine the effect compound on cell viability (S1 S2). Cell morphologies IC50 values obtained. The acridine orange (AO)/ethidium bromide (EB) dual staining technique was determin...

Background: The aim of this study was to fabricate the poly caprolactone (PCL) aligned nanofiber scaffold and to evaluate the survival, adhesion, proliferation, and differentiation of rat hair follicle stem cells (HFSC) in the graft material using electrospun PCL nanofiber scaffold for tissue engineering applications. Methods: The bulge region of rat whisker was isolated and cultured in DMEM: n...

Objective(s): Bone marrow mesenchymal stem cells (MSCs) play an important role in bone health. Cadmium causes osteoporosis, but the exact mechanisms of its effect on MSCs are not known. Materials and Methods: Rats were treated with cadmium chloride (40 mg/l) in drinking water for six weeks, and then the biochemical and morphological studies on MSCs were carried out as a cellular backup for oste...

Glioma is the most frequent primary intracranial tumor worldwide. Dexmedetomidine an efficient anesthetic used in surgery and has impact on glioma. Yet, mechanism of dexmedetomidine biological characteristics glioma cells unknown. Circ_BRAF, microRNA-381-3p thrombospondin 2 was detected via quantitative reverse transcription-polymer chine reaction. Proliferation detection conducted using 3-(4,5...

Vascular muscle cells (VSMCs) participate in the pathophysiology of atherosclerosis. Resistin-like molecule beta (Relmβ) contributes to atherosclerosis development by activating macrophage. This study aims investigate whether Relmβ regulates VSMC phenotypic modulation under high glucose environment. Human aortic vascular smooth were cultured and treated with presence or absence glucose. was ass...

Objective. The ubiquitin-like with PHD and ring finger domains 1 (UHRF1) is a protein coding gene which associated colorectal cancer other diseases. Therefore, the present study was aimed at investigating effect mechanism of UHRF1 on invasion metastasis in human renal carcinoma cells. Methods. After interfered or overexpressed cell lines A498 769-P, relative mRNA level detected by RT-qPCR immun...

Objective: Little knowledge is available on the antimicrobial and antioxidant properties of Coccina grandis fruits and no study has reported on its cell proliferative property. The aim of this study was to examine the antimicrobial, antioxidant and cell proliferative property of fruits of C. grandis. Material and Methods: Fruits of C. grandis were extracted using water; ethanol and acetone by c...