We examined whether a difference in potassium dihydrogenphosphate (KH2PO4) and potassium tripolyphosphate (K5P3O10) as dietary phosphorus sources could differentially effect the nephrocalcinosis and proximal tubular function in female rats. Rats were fed on a diet containing KH2PO4 or K5P3O10, at the normal phosphorus level (normal phosphorus diet) or at a high phosphorus level (high-phosphorus...

Introduction Receptor-mediated endocytosis is responsible for protein reabsorption in the proximal tubules. For albumin this process involves at least 2 interacting receptors, megalin and cubilin. Albumin is not usually present in the urine, indicating a highly efficient tubular reuptake under physiological conditions. However, early appearance of albuminuria may mean that the tubular system is...

Terminal renal failure is the final common fate of chronic nephropathies independent of the type of initial insult. The outstanding review by Brenner et al. (1) in 1982 introduced the idea that glomerular hemodynamic changes that develop as compensatory adaptation to irreversible nephron damage cause progressive deterioration of function and structure of the remaining nephrons. After reduction ...

Capasso et al. show a role of the calcium-sensing receptor (CaSR) in enhancing proximal tubular fluid absorption and urinary acidification by stimulation of luminal Na(+)/H(+) exchanger (NHE) activity. NHE3 is required for sodium and fluid absorption, and its activity is coupled to passive reabsorption of a major fraction of calcium through the paracellular route. These data shed new light on t...

AGUS, ZALMAN S., LAURENCE B. GARDNER, LAURENCE H. BECK, AND MARTIN GOLDBERG. Efects of parathyroid hormone on renal tubular reabsorption of calcium, sodium, and phosphate. Am. J. Physiol. 224(5) : 1143-l 148. 1973.-In order to study the relationships between sodium, calcium, and phosphate reabsorption in the proximal tubule and the effects of parathyroid hormone (PTH) on these relationships, re...

Clinical nephrologists have long recognized the associAfter binding, albumin reabsorption occurs by endocytosis into an intracellular vesicular trafficking system, ation between heavy proteinuria and the tendency for progression of renal failure. Progressive renal impairwith delivery of the majority of the reabsorbed albumin ment is characterized by progressive interstitial scarring to a lysoso...

To investigate the injury effects of organic solvents on kidney, an animal model of Sprague-Dawley (SD) rats treated with mixed organic solvents via inhalation was generated and characterized. The mixed organic solvents consisted of gasoline, dimethylbenzene and formaldehyde (GDF) in the ratio of 2:2:1, and were used at 12,000 PPM to treat the rats twice a day, each for 3 hours. Proteinuria app...

Acute infusions of isotonic saline in the rat cause an increase in glomerular filtration rate and in the excretion of salt and water. The kidney swells, due to expansion of tubular and interstitial volume. Despite the increase in tubular diameter, transit time through the proximal tubules and loops of Henle is decreased, presumably owing to a greatly accelerated rate of tubular flow. Proximal t...

AGUS, ZALMAN S., LAURENCE B. GARDNER, LAURENCE H. BECK, AND MARTIN GOLDBERG. Efects of parathyroid hormone on renal tubular reabsorption of calcium, sodium, and phosphate. Am. J. Physiol. 224(5) : 1143-l 148. 1973.-In order to study the relationships between sodium, calcium, and phosphate reabsorption in the proximal tubule and the effects of parathyroid hormone (PTH) on these relationships, re...