This study examined the diversity of Na+ channel gene expression in intact cardiac tissue and purified myocardial cells. The screening of neonatal rat myocardial cell cDNA libraries with a conserved rat brain Na+ channel cDNA probe, resulted in the isolation and characterization of a putative rat cardiac Na+ channel cDNA probe (pCSC-1). The deduced amino acid sequence of pCSC-1 displayed a stri...

The search for effective pharmacophores to treat ischemic stroke is precipitated by the prevalence and high mortality of condition. Optimization preclinical scenarios promising neuroprotectants mathematical modeling using up-to-date computational platforms a well-defined urgent task. This study aimed develop drug-oriented model represented an ordinary differential equation system pharmacokineti...

the effects of some histaminergic agents were evaluated on stress- induced immunosuppression in immunized nale rats. in rat immunized with sheep red blood cells ( srbcs). restraint stress (rs) prevented the booster-induced rise in anti-srbc antibody titre and cell immunity response. intracerebroventicular (i.c>v) injection of histamine (150 µg/rat) induced a similar effect with rs. pretreatment...

Rat brain models effectively simulate a multitude of human neurological disorders. Improvements in coil design have facilitated the wider utilization of rat brain models by enabling the utilization of clinical MR scanners for image acquisition. In this study, a novel coil design, subsequently referred to as the rat brain coil, is described that exploits and combines the strengths of both soleno...

The activity of aspartate aminotransferase a vitamin B6 containing enzyme was measured in the laysed synaptosomes prepared from rat brain, during development. Administration of vitamin B6 increased the enzyme activity throughout development. The stimulating effect of this vitamin was prevented when the animals were previously treated with D-penicillamine. However, penicillamine alone had n...

A B S T R A C T Introduction: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied the effect of mitochondrial KATP channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. Materials & Methods: Rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with...