Background Infants of diabetic mothers (IDMs) have significantly greater risk for spontaneous abortion, stillbirth, congenital malformations and perinatal mortality and morbidity but whether maternal DM affects the neonatal innate immune system is unknown. We aimed to assess the immune response of infants of diabetic mothers (IDMs) with non-gestational DM for Hepatitis B vaccine and to compare ...

OBJECTIVE To evaluate the efficacy of hepatitis B virus (HBV) vaccine in susceptible spouses at the time of marriage. METHODS From April 2003 to December 2005, 60 cases of susceptible wives of infected husbands and 32 cases of susceptible husbands of the infected wives in Babol north of Iran, received recombinant hepatitis B (HB) vaccine at the time of marriage followed with the second and th...

During the past two decades, advances in biotechnology and increased knowledge of the inductive and effector components of immune responses have revolutionized the field of vaccine development. This has opened a vaccine ‘pipeline’ that has already resulted in the licensure of many new and improved vaccines including recombinant hepatitis B vaccine, acellular pertussis vaccines, and conjugate va...

Hepatitis B is a global serious disease caused by hepatitis B virus (HBV). There is no known cure for hepatitis B. The best way to deal with the disease is by preventing with hepatitis B vaccine. However, the current protein-based vaccines made up of recombinant hepatitis B surface antigen (HBsAg) are ineffective in chronic HBV carriers and a significant number of the vaccinees do not mount the...

The time has come when physicians may be able to practice preventive medicine, which is particularly important in reference to those infectious diseases that can be prevented by immunizations. Even pregnant women should be candidates for certain immunizations. It is the scope of this editorial to cover just two of those immunizations that can be prescribed for pregnant women: the influenza vacc...

Hepatitis B: Hepatitis B infection can be prevented. If your work or lifestyle exposes you to the virus, we encourage you to get a Hepatitis B vaccine. If you have not had Hepatitis B vaccine, you can begin your Hepatitis B vaccine series immediately after being exposed. Hepatitis C: There is no vaccine to prevent Hepatitis C. If exposed, you must be tested regularly to make sure you have not b...

     Thimerosal, which is approximately 50% mercury by weight is a preservative widely used in vaccines since the 1930’s. It meets the requirements for a preservative as set forth by Pharmacopeia challenge test and has been shown to be effective against a broad spectrum of pathogens. In July 1999, the Public Health Service agencies and vaccine manufacturers agreed that thimerosal should be redu...

OBJECTIVE To analyze the efficacy and safety of a recombinant Hepatitis B vaccine in newborns. METHODS The study was carried out in a general hospital in the city of Guarulhos, Southeastern Brazil, between 2002 and 2005. The recombinant Hepatitis B vaccine from Instituto Butantan (VrHB-IB) was tested in two clinical trials. In both trials, newborns were randomly allocated to the experimental ...