1 Slc26a9 is inhibited by the R-region of CFTR via the STAS domain Min-Hwang Chang, Consuelo Plata, Aleksandra Sinđić , Wasantha K. Ranatunga, An-Ping Chen, Kambiz Zandi-Nejad, Kim W. Chan, James Thompson, David B. Mount, Michael F. Romero § Physiology & Biophysics, Case Western Reserve University, Cleveland, OH 44106 Physiology & Biomedical Engineering, Mayo Clinic College of Medicine, Rochest...

Before discussing clinical application and its complications, it is extremely important to have an understanding of the relevant peritoneal anatomy and physiology. In essence PD involves the transport of solutes and water across a ‘membrane’ that separates two fluid containing compartments: 1. Blood in peritoneal capillaries, which contains uremic toxins 2. Dialysis solution in the peritoneal c...

INTRODUCTION Teaching renal physiology for undergraduate medical students in an understandable way using methods which improve their deep learning has always been a problem. In this study, Early Clinical Exposure (ECE) was used in teaching renal physiology for the second year medical students in Shiraz Medical School. This article aims to introduce and develop this program and also measure the ...

RATIONALE Pulmonary complications of sickle cell anemia (Hb-SS) commonly cause morbidity, yet few large studies of pulmonary function tests (PFTs) in this population have been reported. OBJECTIVES PFTs (spirometry, lung volumes, and diffusion capacity for carbon monoxide [DLCO]) from 310 adults with Hb-SS were analyzed to determine the pattern of pulmonary dysfunction and their association wi...

pressures in proximal tubules and peritubule capillaries in the dog. Kidney Int 2: 11-16, 1972 40 35. Abe Y: Intrarenal blood flow distribution and autoregulation of renal blood flow and glomerular filtration rate. Jap Circ J 35: 1163-1173, 1971 41 36. McNay JL, Abe Y: Pressure dependent heterogeneity of renal cortical blood flow in dogs. Circ Res 27: 571-587, 1970 37. Gottschalk CW, Mylle M: M...

Mathematical models and simulations are important tools in discovering key causal relationships governing physiological processes. Simulations guide and improve outcomes of medical interventions involving complex physiology. We developed HumMod, a Windows-based model of integrative human physiology. HumMod consists of 5000 variables describing cardiovascular, respiratory, renal, neural, endocri...

The development of perioperative acute renal failure is associated with a high incidence of morbidity and mortality. Although this incidence varies with different surgical procedures and with the definition used for renal failure, we now understand better the aetiology of the underlying problem. However, successful strategies to provide renal protection or strategies for 'rescue therapy' are ei...

In-utero the placenta is the primary organ responsible for neonatal homeostasis of fluid and electrolyte balance. With birth, this responsibility now transitions to the neonatal kidney. For successful transition to extrauterine renal physiology to occur maturation of neonatal glomerular filtration must occur, which is dependent on the development of renal blood flow. While these functions are d...

Translationally controlled tumor protein is a multifaceted protein involved in several physiological and biological functions. Its expression in normal kidney and in renal carcinomas, once corroborated by functional data, may add elements to elucidate renal physiology and carcinogenesis. In this study, translationally controlled tumor protein expression was evaluated by quantitative real time p...

Exchange proteins directly activated by cAMP [Epac(s)] were discovered more than a decade ago as new sensors for the second messenger cAMP. The Epac family members, including Epac1 and Epac2, are guanine nucleotide exchange factors for the Ras-like small GTPases Rap1 and Rap2, and they function independently of protein kinase A. Given the importance of cAMP in kidney homeostasis, several molecu...